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wrb-1 Guided entry of tail-anchored proteins factor 1 [ Caenorhabditis elegans ]

Gene ID: 178617, updated on 4-Jan-2025

Summary

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Official Symbol
wrb-1
Official Full Name
Guided entry of tail-anchored proteins factor 1
Primary source
WormBase:WBGene00021736
Locus tag
CELE_Y50D4A.2
See related
AllianceGenome:WB:WBGene00021736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-membrane adaptor activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of GET complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See wrb-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (1196072..1197141)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mic1 domain-containing protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Reverse transcriptase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unique Features of Satellite DNA Transcription in Different Tissues of Caenorhabditis elegans. Subirana JA, et al. Int J Mol Sci, 2023 Feb 3. PMID 36769294, Free PMC Article
  2. Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans. Raj D, et al. Sci Rep, 2021 Apr 21. PMID 33883621, Free PMC Article
  3. Functional transcriptomics of a migrating cell in Caenorhabditis elegans. Schwarz EM, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22991463, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GET complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Guided entry of tail-anchored proteins factor 1
NP_001255993.1
  • Confirmed by transcript evidence
NP_001379795.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1196072..1197141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269064.4 → NP_001255993.1  Guided entry of tail-anchored proteins factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255993.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WTM8
    Conserved Domains (1) summary
    pfam04420
    Location:24 → 122
    CHD5; CHD5-like protein

  2. NM_001392472.1 → NP_001379795.1  Guided entry of tail-anchored proteins factor 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4S708
    Conserved Domains (1) summary
    pfam04420
    Location:10 → 118
    CHD5; CHD5-like protein
Nucleotide Protein
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