Myb myeloblastosis oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mybprovided by MGI
Official Full Name: myeloblastosis oncogeneprovided by MGI
Primary source: MGI:MGI:97249
See related: Ensembl:ENSMUSG00000019982 AllianceGenome:MGI:97249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: c-myb
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to cytokine stimulus; hematopoietic or lymphoid organ development; and hemopoiesis. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study essential thrombocythemia and myelofibrosis. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 78.6), liver E14 (RPKM 10.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.75 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (21000829..21036883, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (21124930..21160984, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming.
Title: MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming.
MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia.
Title: MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia.
MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer.
Title: MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer.
Overexpression of MYB in the Skin Induces Alopecia and Epidermal Hyperplasia.
Title: Overexpression of MYB in the Skin Induces Alopecia and Epidermal Hyperplasia.
c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells.
Title: c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells.
Transcriptional profiling revealed that c-Myb has a limited effect on B cell function but is integral in maintaining B cell progenitor populations in the bone marrow.
Title: c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.
These results show that reducing Myb activity can override the differentiation barrier, although the dependency on Myb expression generally observed in leukaemia is minimal in the presence of CEBPA biallelic N-terminal mutations.
Title: Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations.
These findings reveal a novel molecular mechanism for gene regulation via Notch signaling through the recruitment of RUNX1 and MYB to enhancer chromatin during thymocyte development.
Title: Notch Signaling Controls Transcription via the Recruitment of RUNX1 and MYB to Enhancers during T Cell Development.
Findings identify myb proto-oncogene protein (c-Myb) as a pivotal regulator of CD8(+) T cell stemness and suggest its therapeutic potential.
Title: The transcription factor c-Myb regulates CD8(+) T cell stemness and antitumor immunity.
Low c-myb expression promotes breast cancer lung metastasis.
Title: Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding.

Submit: New GeneRIF Correction See all GeneRIFs (105)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (5) 1 citation
Endonuclease-mediated (2)
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC202376P1 (e-PCR)
- UniSTS:271887

NoName (e-PCR)
- UniSTS:225042

AI550390 (e-PCR)
- UniSTS:180014

Myb (e-PCR), detects polymorphism
- UniSTS:143940

D11Bir11 (e-PCR), detects polymorphism
- UniSTS:141709

D11Bir7 (e-PCR), detects polymorphism
- UniSTS:141711

Myb (e-PCR), detects polymorphism
- UniSTS:516504

MYB-544R (e-PCR)
- UniSTS:72380

Myb (e-PCR), detects polymorphism
- UniSTS:507077

M16449 (e-PCR)
- UniSTS:159959

UniSTS:224764 (e-PCR)
- UniSTS:224764

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables WD40-repeat domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-6	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in myeloid cell development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of testosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcriptional activator Myb

Names: gag-myb protein; myb proto-oncogene protein; myeloblastosis proto-oncogene product; proto-oncogene c-Myb; tumor-specific myb protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198914.2 → NP_001185843.1 transcriptional activator Myb isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC153556

Consensus CDS

CCDS78800.1

UniProtKB/TrEMBL

A0A087WPA7, Q8BU17

Related

ENSMUSP00000139699.2, ENSMUST00000188495.8

Conserved Domains (4) summary

smart00717
Location:92 → 140

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:92 → 138

Myb_DNA-binding; Myb-like DNA-binding domain

pfam07988
Location:269 → 313

LMSTEN; LMSTEN motif

pfam09316
Location:516 → 677

Cmyb_C; C-myb, C-terminal
NM_010848.3 → NP_034978.3 transcriptional activator Myb isoform 2

See identical proteins and their annotated locations for NP_034978.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AA170760, AC153556, AK132250, AK137794, AK137965, BB543454, M12848

Consensus CDS

CCDS35861.1

UniProtKB/Swiss-Prot

E9QMG8, P06876, Q61929

UniProtKB/TrEMBL

Q61421

Related

ENSMUSP00000020158.7, ENSMUST00000020158.9

Conserved Domains (4) summary

smart00717
Location:92 → 140

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:92 → 138

Myb_DNA-binding; Myb-like DNA-binding domain

pfam07988
Location:269 → 313

LMSTEN; LMSTEN motif

pfam09316
Location:401 → 558

Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

21000829..21036883 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033597.1: Suppressed sequence

Description

NM_033597.1: This RefSeq was permanently suppressed because it is based on M16449.1 which is from lymphosarcoma tissue. Other evidence for this transcript in non-cancerous tissues does not exist.