F22F7.7 Gamma-glutamylcyclotransferase;glutathione-specific gamma-glutamylcyclotransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F22F7.7
Official Full Name: Gamma-glutamylcyclotransferase;glutathione-specific gamma-glutamylcyclotransferase
Primary source: WormBase:WBGene00017724
Locus tag: CELE_F22F7.7
See related: AllianceGenome:WB:WBGene00017724
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process. Located in striated muscle dense body. Orthologous to several human genes including CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F22F7.7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (2131475..2140042, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

F22F7.7 (e-PCR)
- UniSTS:322079

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables gamma-glutamylcyclotransferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: Gamma-glutamylcyclotransferase;glutathione-specific gamma-glutamylcyclotransferase

NP_001300087.1

Confirmed by transcript evidence

NP_001300088.1

Partially confirmed by transcript evidence

NP_503578.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2131475..2140042 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071177.4 → NP_503578.1 glutathione-specific gamma-glutamylcyclotransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503578.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GZE8

Conserved Domains (2) summary

COG3703
Location:50 → 230

ChaC; Cation transport regulator ChaC [Inorganic ion transport and metabolism]

pfam04752
Location:50 → 228

ChaC; ChaC-like protein
NM_001313158.3 → NP_001300087.1 glutathione-specific gamma-glutamylcyclotransferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARZ2

Conserved Domains (2) summary

COG3703
Location:13 → 193

ChaC; Cation transport regulator ChaC [Inorganic ion transport and metabolism]

pfam04752
Location:13 → 191

ChaC; ChaC-like protein
NM_001313159.3 → NP_001300088.1 Gamma-glutamylcyclotransferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVG7

Conserved Domains (1) summary

cl22886
Location:1 → 87

GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...