gst-10 GST C-terminal domain-containing protein;Glutathione S-transferase P 10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gst-10
Official Full Name: GST C-terminal domain-containing protein;Glutathione S-transferase P 10
Primary source: WormBase:WBGene00001758
Locus tag: CELE_Y45G12C.2
See related: AllianceGenome:WB:WBGene00001758
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables glutathione transferase activity. Involved in several processes, including determination of adult lifespan; heat acclimation; and response to hydrogen peroxide. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and tail. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); eye disease (multiple); hematopoietic system disease (multiple); and respiratory system disease (multiple). Orthologous to several human genes including GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gst-10 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (2561690..2564645)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56A4.i (e-PCR)
- UniSTS:322561

Y45G12C.2 (e-PCR)
- UniSTS:322415

Y45G12C.13 (e-PCR)
- UniSTS:317429

F56A4.d (e-PCR)
- UniSTS:322559

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutathione transferase activity	TAS Traceable Author Statement more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GST C-terminal domain-containing protein;Glutathione S-transferase P 10

NP_001303772.1

Confirmed by transcript evidence

NP_503701.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2561690..2564645

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071300.9 → NP_503701.1 Glutathione S-transferase P 10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503701.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N4X8

Conserved Domains (3) summary

PTZ00057
Location:6 → 196

PTZ00057; glutathione s-transferase; Provisional

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

cl02776
Location:84 → 208

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001316843.3 → NP_001303772.1 GST C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0M7RDX7

Conserved Domains (1) summary

cl02776
Location:1 → 117

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family