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irg-3 Infection Response Gene [ Caenorhabditis elegans ]

Gene ID: 178726, updated on 9-Dec-2024

Summary

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Official Symbol
irg-3
Official Full Name
Infection Response Gene
Primary source
WormBase:WBGene00018760
Locus tag
CELE_F53E10.4
See related
AllianceGenome:WB:WBGene00018760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in innate immune response. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See irg-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (2592591..2595062)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF5683 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene BZIP domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. Lo Sasso G, et al. PLoS One, 2014. PMID 25013930, Free PMC Article
  2. bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans. Estes KA, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20133860, Free PMC Article
  3. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Irazoqui JE, et al. Proc Natl Acad Sci U S A, 2008 Nov 11. PMID 18981407, Free PMC Article
  4. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. Troemel ER, et al. PLoS Genet, 2006 Nov 10. PMID 17096597, Free PMC Article
  5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 

General protein information

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Preferred Names
Infection Response Gene
NP_001303734.1
  • Product from WormBase gene class irg;
    Confirmed by transcript evidence
NP_001303735.1
  • Product from WormBase gene class irg;
    Confirmed by transcript evidence
NP_503711.1
  • Product from WormBase gene class irg;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    2592591..2595062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071310.6 → NP_503711.1  Infection Response Gene [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503711.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91316

  2. NM_001316805.3 → NP_001303734.1  Infection Response Gene [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M7RF66

  3. NM_001316806.3 → NP_001303735.1  Infection Response Gene [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M7REP5
Nucleotide Protein
Heading Accession and Version

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