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lag-2 Protein lag-2 [ Caenorhabditis elegans ]

Gene ID: 178755, updated on 2-Nov-2024

Summary

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Official Symbol
lag-2
Official Full Name
Protein lag-2
Primary source
WormBase:WBGene00002246
Locus tag
CELE_Y73C8B.4
See related
AllianceGenome:WB:WBGene00002246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables Notch binding activity. Involved in several processes, including maintenance of dauer; positive regulation of stem cell proliferation; and regulation of basement membrane organization. Located in cell projection membrane and neuronal cell body membrane. Is expressed in several structures, including CAN; distal tip cell; head neurons; somatic gonad precursor; and vulval cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lag-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (3188343..3190115)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene Transposase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modelling the Caenorhabditis elegans gonad over developmental time using the Distal Tip Cell marker lag-2p::gfp. Crook M, et al. MicroPubl Biol, 2022. PMID 36060032, Free PMC Article
  2. A DTC niche plexus surrounds the germline stem cell pool in Caenorhabditis elegans. Byrd DT, et al. PLoS One, 2014. PMID 24586318, Free PMC Article
  3. Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina. Margalit A, et al. Proc Natl Acad Sci U S A, 2005 Mar 1. PMID 15728376, Free PMC Article
  4. Higher-order epistasis shapes natural variation in germ stem cell niche activity. Fausett SR, et al. Nat Commun, 2023 May 17. PMID 37198172, Free PMC Article
  5. An in vivo toolkit to visualize endogenous LAG-2/Delta and LIN-12/Notch signaling in C. elegans. Medwig-Kinney TN, et al. MicroPubl Biol, 2022. PMID 35966395, Free PMC Article

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
enables Notch binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of dauer IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lag-2
NP_503877.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    3188343..3190115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071476.3 → NP_503877.1  Protein lag-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503877.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45442
    Conserved Domains (1) summary
    smart00051
    Location:103 → 166
    DSL; delta serrate ligand
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45442.1

Gene LinkOut

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