apx-1 Anterior pharynx in excess protein 1;Delta-like protein;EGF-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: apx-1
Official Full Name: Anterior pharynx in excess protein 1;Delta-like protein;EGF-like domain-containing protein
Primary source: WormBase:WBGene00000168
Locus tag: CELE_K08D9.3
See related: AllianceGenome:WB:WBGene00000168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Notch binding activity. Involved in several processes, including lateral inhibition; regulation of germ cell proliferation; and regulation of vulval development. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including AB; C; P6.p hermaphrodite; non-striated muscle; and vulva. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See apx-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (3210196..3223221)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of apx-1 causes an endomitotic oocyte phenotype and ovulation defects, which are often accompanied by a delay of spermathecal distal neck closure after oocyte entry, Abnormal oocytes and neck closure defects are seen occasionally when apx-1 activity is reduced in adult animals, suggesting a possible post-developmental role for APX-1 signaling in ovulation.
Title: The DSL ligand APX-1 is required for normal ovulation in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08D9.3 (e-PCR)
- UniSTS:322233

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior axis specification, embryo	NAS Non-traceable Author Statement more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Anterior pharynx in excess protein 1;Delta-like protein;EGF-like domain-containing protein

NP_001305192.1

Confirmed by transcript evidence

NP_001360546.1

Confirmed by transcript evidence

NP_503882.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

3210196..3223221

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373012.2 → NP_001360546.1 Delta-like protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WTV8

Conserved Domains (1) summary

cl19567
Location:108 → 172

DSL; Delta serrate ligand
NM_071481.6 → NP_503882.2 Anterior pharynx in excess protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503882.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P41990, Q9TXN4

Conserved Domains (1) summary

cl19567
Location:108 → 172

DSL; Delta serrate ligand
NM_001318263.3 → NP_001305192.1 EGF-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S4XRY4