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Myf5 myogenic factor 5 [ Mus musculus (house mouse) ]

Gene ID: 17877, updated on 27-Nov-2024

Summary

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Official Symbol
Myf5provided by MGI
Official Full Name
myogenic factor 5provided by MGI
Primary source
MGI:MGI:97252
See related
Ensembl:ENSMUSG00000000435 AllianceGenome:MGI:97252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myf-5; bHLHc2; B130010J22Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including positive regulation of transcription by RNA polymerase II; skeletal muscle cell differentiation; and skeletal system morphogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and musculature. Orthologous to human MYF5 (myogenic factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 2.7), ovary adult (RPKM 0.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Myf5 in Genome Data Viewer
Location:
10 D1; 10 55.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107318769..107322787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (107482908..107486927, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29674 Neighboring gene lin-7 homolog A, crumbs cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_27782 Neighboring gene STARR-seq mESC enhancer starr_27784 Neighboring gene myogenic factor 6 Neighboring gene STARR-seq mESC enhancer starr_27785 Neighboring gene protein tyrosine phosphatase receptor type Q

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Kan L, et al. Stem Cells, 2009 Jan. PMID 18832590, Free PMC Article
  2. Myf5 expression in somites and limb buds of mouse embryos is controlled by two distinct distal enhancer activities. Buchberger A, et al. Development, 2003 Jul. PMID 12783799
  3. The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis. Teboul L, et al. Development, 2002 Oct. PMID 12223413
  4. Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements. Zammit PS, et al. Dev Biol, 2004 Sep 15. PMID 15328025
  5. Modular long-range regulation of Myf5 reveals unexpected heterogeneity between skeletal muscles in the mouse embryo. Hadchouel J, et al. Development, 2000 Oct. PMID 11003844

See all (573) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.
    Title: A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.
  2. Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
    Title: Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
  3. PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
    Title: PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
  4. MLL1 facilitates proliferation of myoblasts and Pax7-positive satellite cells by epigenetically regulating Myf5.
    Title: MLL1 promotes myogenesis by epigenetically regulating Myf5.
  5. The induction phase of primary Myf5+ brown adipogenesis.
    Title: STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis.
  6. Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7.
    Title: The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
  7. An absolute requirement for either MyoD or Myf5 in muscle regeneration.
    Title: Loss of MyoD and Myf5 in Skeletal Muscle Stem Cells Results in Altered Myogenic Programming and Failed Regeneration.
  8. Novel RNA-binding activity of MYF5 enhances Ccnd1 mRNA translation during myogenesis.
    Title: Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.
  9. Transcription of the skeletal muscle program is achieved by the expression of MyoD, which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites
    Title: Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation.
  10. The Myf5- and Myogenin-deficient mice showed a partial or complete, respectively, loss of TMC in an otherwise regularly structured thymus.
    Title: Myf5 and Myogenin in the development of thymic myoid cells - Implications for a murine in vivo model of myasthenia gravis.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific TAS
Traceable Author Statement
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
myogenic factor 5
Names
myogenic regulatory factor MYF-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008656.5 → NP_032682.1  myogenic factor 5

    See identical proteins and their annotated locations for NP_032682.1

    Status: VALIDATED

    Source sequence(s)
    AK044894, AK083402
    Consensus CDS
    CCDS24161.1
    UniProtKB/Swiss-Prot
    P24699, Q543W7
    UniProtKB/TrEMBL
    A2RSK4
    Related
    ENSMUSP00000000445.2, ENSMUST00000000445.2
    Conserved Domains (3) summary
    smart00520
    Location:1 → 88
    BASIC; Basic domain in HLH proteins of MYOD family
    pfam12232
    Location:143 → 214
    Myf5; Myogenic determination factor 5
    cd18937
    Location:83 → 146
    bHLH_TS_Myf5; basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    107318769..107322787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513319.3 → XP_006513382.1  myogenic factor 5 isoform X1

    See identical proteins and their annotated locations for XP_006513382.1

    UniProtKB/Swiss-Prot
    P24699, Q543W7
    UniProtKB/TrEMBL
    A2RSK4
    Conserved Domains (3) summary
    smart00520
    Location:1 → 88
    BASIC; Basic domain in HLH proteins of MYOD family
    pfam12232
    Location:143 → 214
    Myf5; Myogenic determination factor 5
    cd18937
    Location:83 → 146
    bHLH_TS_Myf5; basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24699.1 GenPept UniProtKB/Swiss-Prot:P24699

Gene LinkOut

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