pygl-1 Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pygl-1
Official Full Name: Alpha-1,4 glucan phosphorylase
Primary source: WormBase:WBGene00020696
Locus tag: CELE_T22F3.3
See related: AllianceGenome:WB:WBGene00020696
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glycogen phosphorylase activity and pyridoxal phosphate binding activity. Predicted to be involved in glycogen catabolic process. Predicted to be active in cytoplasm. Is expressed in germ line. Used to study glycogen storage disease. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease V; glycogen storage disease VI; and lactic acidosis. Orthologous to several human genes including PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pygl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (3579023..3585042)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F40C5.a (e-PCR)
- UniSTS:324231

F40C5.c (e-PCR)
- UniSTS:324232

T22F3.3 (e-PCR)
- UniSTS:310959

F40C5.e (e-PCR)
- UniSTS:322532

F40C5.h (e-PCR)
- UniSTS:322535

F40C5.b (e-PCR)
- UniSTS:324587

F40C5.d (e-PCR)
- UniSTS:324588

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Alpha-1,4 glucan phosphorylase

NP_001309657.1

Confirmed by transcript evidence

NP_001317772.1

Confirmed by transcript evidence

NP_001379943.1

Confirmed by transcript evidence

NP_504007.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

3579023..3585042

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071606.5 → NP_504007.1 Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504007.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N5U1

Conserved Domains (2) summary

cd04300
Location:63 → 865

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:66 → 865

P_ylase; glycogen/starch/alpha-glucan phosphorylases
NM_001392495.1 → NP_001379943.1 Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q86NC1

Conserved Domains (1) summary

cd04300
Location:27 → 829

GT35_Glycogen_Phosphorylase; glycogen phosphorylase and similar proteins
NM_001330794.3 → NP_001317772.1 Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MCL1
NM_001322539.3 → NP_001309657.1 Alpha-1,4 glucan phosphorylase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MDC6

Conserved Domains (1) summary

cl10013
Location:1 → 231

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...