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pgl-3 Guanyl-specific ribonuclease pgl-3 [ Caenorhabditis elegans ]

Gene ID: 178867, updated on 9-Dec-2024

Summary

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Official Symbol
pgl-3
Official Full Name
Guanyl-specific ribonuclease pgl-3
Primary source
WormBase:WBGene00003994
Locus tag
CELE_C18G1.4
See related
AllianceGenome:WB:WBGene00003994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA endonuclease activity and identical protein binding activity. Located in P granule. Is expressed in Psub1 and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pgl-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (4755979..4758587)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Histone H1.4 Neighboring gene ncRNA Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog;Glyco_trans_2-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient production of monoclonal antibodies recognizing specific structures in Caenorhabditis elegans embryos using an antigen subtraction method. Takeda K, et al. Genes Cells, 2008 Jul. PMID 18498356
  2. Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps. Jawerth LM, et al. Phys Rev Lett, 2018 Dec 21. PMID 30608810
  3. The P granule antibody KT3 recognizes epitopes in both PGL-1 and PGL-3. Danlasky BM, et al. MicroPubl Biol, 2024. PMID 38440332, Free PMC Article
  4. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. Hanazawa M, et al. J Cell Biol, 2011 Mar 21. PMID 21402787, Free PMC Article
  5. Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism. Saha S, et al. Cell, 2016 Sep 8. PMID 27594427, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study demonstrates that germ-granule components, PGL-1 and PGL-3, can serve as negative regulators of apoptosis not only in the germline but also in the soma in C. elegans.
    Title: Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.
  2. PGL-1 and PGL-3 control germline apoptosis in C. elegans.
    Title: Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.
  3. we demonstrated that mutations in C. elegans epg-11 cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known as PGL granules, from somatic cells during embryogenesis
    Title: Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.
  4. Data show that the PGL proteins PGL-1 and PGL-3 serve as the scaffold for germ granule formation in Caenorhabditis elegans.
    Title: PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonuclease T1 activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular organelle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Guanyl-specific ribonuclease pgl-3
NP_504278.1
  • Confirmed by transcript evidence
NP_504279.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4755979..4758587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071878.5 → NP_504279.1  Guanyl-specific ribonuclease pgl-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504279.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBV6

  2. NM_071877.7 → NP_504278.1  Guanyl-specific ribonuclease pgl-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504278.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBV6, Q965J2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBV6.1

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