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gcst-1 Aminomethyltransferase [ Caenorhabditis elegans ]

Gene ID: 178960, updated on 9-Dec-2024

Summary

Official Symbol
gcst-1
Official Full Name
Aminomethyltransferase
Primary source
WormBase:WBGene00017765
Locus tag
CELE_F25B4.1
See related
AllianceGenome:WB:WBGene00017765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aminomethyltransferase activity and transaminase activity. Predicted to be involved in glycine catabolic process. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See gcst-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (5712928..5714737)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein pellino Neighboring gene Neuropeptide CCHamide-1 Neighboring gene ncRNA Neighboring gene Rho-GAP domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glycine catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Aminomethyltransferase
NP_504502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5712928..5714737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072101.6NP_504502.1  Aminomethyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22968
    Conserved Domains (3) summary
    PLN02319
    Location:2399
    PLN02319; aminomethyltransferase
    pfam01571
    Location:34287
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:297391
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain