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F44E7.4 Insulin-degrading enzyme [ Caenorhabditis elegans ]

Gene ID: 178966, updated on 9-Dec-2024

Summary

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Official Symbol
F44E7.4
Official Full Name
Insulin-degrading enzyme
Primary source
WormBase:WBGene00018426
Locus tag
CELE_F44E7.4
See related
AllianceGenome:WB:WBGene00018426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis involved in protein catabolic process. Predicted to be active in cytosol and mitochondrion. Is expressed in gonad. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F44E7.4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (5772831..5776953, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Phosphoglycolate phosphatase Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene pseudo Neighboring gene F-box domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Insulin-degrading enzyme
NP_001023928.1
  • Confirmed by transcript evidence
NP_504514.2
  • Confirmed by transcript evidence
NP_741542.1
  • Confirmed by transcript evidence
NP_741543.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5772831..5776953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171929.7 → NP_741543.1  Insulin-degrading enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16249
    Conserved Domains (4) summary
    COG1025
    Location:75 → 1039
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:95 → 233
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:259 → 436
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:444 → 744
    Peptidase_M16_M; Middle or third domain of peptidase_M16

  2. NM_072113.8 → NP_504514.2  Insulin-degrading enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504514.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IA89
    Conserved Domains (4) summary
    COG1025
    Location:16 → 980
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:36 → 174
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:200 → 377
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:385 → 685
    Peptidase_M16_M; Middle or third domain of peptidase_M16

  3. NM_171461.5 → NP_741542.1  Insulin-degrading enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXK1
    Conserved Domains (4) summary
    COG1025
    Location:75 → 1023
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:95 → 233
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:259 → 436
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:444 → 728
    Peptidase_M16_M; Middle or third domain of peptidase_M16

  4. NM_001028757.6 → NP_001023928.1  Insulin-degrading enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6A598
    Conserved Domains (4) summary
    COG1025
    Location:75 → 982
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:95 → 233
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:259 → 436
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:444 → 744
    Peptidase_M16_M; Middle or third domain of peptidase_M16
Nucleotide Protein
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