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smut-1 Synthetic MUTator [ Caenorhabditis elegans ]

Gene ID: 178996, updated on 4-Jan-2025

Summary

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Official Symbol
smut-1
Official Full Name
Synthetic MUTator
Primary source
WormBase:WBGene00021391
Locus tag
CELE_Y38A10A.6
See related
AllianceGenome:WB:WBGene00021391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and nucleic acid binding activity. Is expressed in embryonic cell and germ cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See smut-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (6097105..6099083)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF38 domain-containing protein Neighboring gene N-alpha-acetyltransferase 40 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Calreticulin Neighboring gene DNA-directed DNA polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Seo M, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195740, Free PMC Article
  2. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. Rogers AK, et al. MicroPubl Biol, 2020. PMID 32542232, Free PMC Article
  3. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. Uebel CJ, et al. PLoS Genet, 2018 Jul. PMID 30036386, Free PMC Article
  4. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Phillips CM, et al. Curr Biol, 2014 Apr 14. PMID 24684932, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
    Title: MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Synthetic MUTator
NP_504574.1
  • Product from WormBase gene class smut;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6097105..6099083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072173.8 → NP_504574.1  Synthetic MUTator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504574.1

    Status: REVIEWED

    Conserved Domains (3) summary
    COG0513
    Location:117 → 520
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00270
    Location:116 → 297
    DEAD; DEAD/DEAH box helicase
    pfam00271
    Location:350 → 469
    Helicase_C; Helicase conserved C-terminal domain
Nucleotide Protein
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