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sago-1 Piwi-like protein [ Caenorhabditis elegans ]

Gene ID: 179016, updated on 4-Jan-2025

Summary

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Official Symbol
sago-1
Official Full Name
Piwi-like protein
Primary source
WormBase:WBGene00019666
Locus tag
CELE_K12B6.1
See related
AllianceGenome:WB:WBGene00019666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sago-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (6303771..6308337)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Activin_recp domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Gu SG, et al. Nat Genet, 2012 Jan 8. PMID 22231482, Free PMC Article
  2. New Strains for Tissue-Specific RNAi Studies in Caenorhabditis elegans. Watts JS, et al. G3 (Bethesda), 2020 Nov 5. PMID 32943454, Free PMC Article
  3. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions. Seroussi U, et al. Elife, 2023 Feb 15. PMID 36790166, Free PMC Article
  4. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Yigit E, et al. Cell, 2006 Nov 17. PMID 17110334
  5. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Grishok A, et al. Cell, 2001 Jul 13. PMID 11461699

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Piwi-like protein
NP_504610.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6303771..6308337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072209.5 → NP_504610.1  Piwi-like protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504610.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0T7CIX3
    Conserved Domains (2) summary
    smart00949
    Location:281 → 412
    PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
    cd02826
    Location:443 → 844
    Piwi-like; Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...
Nucleotide Protein
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