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W02F12.4 Exonuclease domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179062, updated on 2-Nov-2024

Summary

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Official Symbol
W02F12.4
Official Full Name
Exonuclease domain-containing protein
Primary source
WormBase:WBGene00020949
Locus tag
CELE_W02F12.4
See related
AllianceGenome:WB:WBGene00020949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1) and TREX2 (three prime repair exonuclease 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See W02F12.4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (6704549..6706934, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Alkaline ceramidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Embryonic mRna (mRNA) Anterior Neighboring gene Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Exonuclease domain-containing protein
NP_001024182.2
  • Confirmed by transcript evidence
NP_001024183.2
  • Confirmed by transcript evidence
NP_001024184.2
  • Confirmed by transcript evidence
NP_001256068.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6704549..6706934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029013.4 → NP_001024184.2  Exonuclease domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024184.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7E2K4

  2. NM_001029012.4 → NP_001024183.2  Exonuclease domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024183.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0G0

  3. NM_001029011.6 → NP_001024182.2  Exonuclease domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024182.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0F9

  4. NM_001269139.2 → NP_001256068.1  Exonuclease domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZUX4
    Conserved Domains (1) summary
    cl10012
    Location:59 → 265
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
Nucleotide Protein
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