unc-70 Spectrin beta chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-70
Official Full Name: Spectrin beta chain
Primary source: WormBase:WBGene00006803
Locus tag: CELE_K11C4.3
See related: AllianceGenome:WB:WBGene00006803
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including dendrite development; embryonic body morphogenesis; and muscle cell cellular homeostasis. Located in cell junction; contractile muscle fiber; and lateral plasma membrane. Is expressed in several structures, including hermaphrodite gonad; intestinal muscle; nervous system; vulval cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14; hereditary spherocytosis; hereditary spherocytosis type 2; and spinocerebellar ataxia type 5. Orthologous to several human genes including SPTB (spectrin beta, erythrocytic). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-70 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (6881338..6891839)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors propose a model in which mechanically resistant epidermal attachment structures are maintained by UNC-70/beta-spectrin and TBC-10 during movement, preventing axonal detachment and degeneration.
Title: Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration.
the spectrin cytoskeleton composed of SPC-1/alpha-spectrin, UNC-70/beta-spectrin, and SMA-1/beta heavy-spectrin as required for contractility and actin organization in the myoepithelial cells of the C. elegans spermathecal, were identified.
Title: Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.
The authors conclude that the spectrin and microtubule cytoskeletons work in combination to protect axons and dendrites from mechanical stress and propose that defects in beta-spectrin and tau may sensitize neurons to damage.
Title: Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling.
Unc-70 is held under constitutive tension in living animals, which contributes to elevated pre-stress in touch receptor neurons.
Title: Mechanical control of the sense of touch by β-spectrin.
beta-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans
Title: Axons break in animals lacking beta-spectrin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11C4.3 (e-PCR)
- UniSTS:311550

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of spectrin	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Spectrin beta chain

NP_001024052.1

Confirmed by transcript evidence

NP_001024053.2

Confirmed by transcript evidence

NP_001256073.1

Confirmed by transcript evidence

NP_001294672.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6881338..6891839

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028882.5 → NP_001024053.2 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024053.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95ZL8, Q9U9J8

Conserved Domains (6) summary

smart00150
Location:2010 → 2088

SPEC; Spectrin repeats

cd00014
Location:160 → 264

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1161 → 1370

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2165 → 2266

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2166 → 2266

PH; PH domain

pfam00307
Location:41 → 139

CH; Calponin homology (CH) domain
NM_001028881.5 → NP_001024052.1 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024052.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EG85

Conserved Domains (6) summary

smart00150
Location:2010 → 2088

SPEC; Spectrin repeats

cd00014
Location:160 → 264

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1161 → 1370

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2120 → 2221

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2121 → 2221

PH; PH domain

pfam00307
Location:41 → 139

CH; Calponin homology (CH) domain
NM_001307743.4 → NP_001294672.1 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294672.1

Status: REVIEWED

UniProtKB/TrEMBL

S6FN00

Conserved Domains (6) summary

smart00150
Location:2010 → 2088

SPEC; Spectrin repeats

cd00014
Location:160 → 264

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1161 → 1370

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2148 → 2249

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2149 → 2249

PH; PH domain

pfam00307
Location:41 → 139

CH; Calponin homology (CH) domain
NM_001269144.3 → NP_001256073.1 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256073.1

Status: REVIEWED

UniProtKB/TrEMBL

E0AHA7

Conserved Domains (6) summary

smart00150
Location:2079 → 2157

SPEC; Spectrin repeats

cd00014
Location:229 → 333

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1230 → 1439

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2189 → 2290

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2190 → 2290

PH; PH domain

pfam00307
Location:110 → 208

CH; Calponin homology (CH) domain