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unc-68 Ryanodine receptor [ Caenorhabditis elegans ]

Gene ID: 179080, updated on 2-Nov-2024

Summary

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Official Symbol
unc-68
Official Full Name
Ryanodine receptor
Primary source
WormBase:WBGene00006801
Locus tag
CELE_K11C4.5
See related
AllianceGenome:WB:WBGene00006801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Is expressed in body wall musculature; intestine; muscle cell; and neurons. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; congestive heart failure (multiple); hepatocellular carcinoma; intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-68 in Genome Data Viewer
Location:
chromosome: V
Exon count:
51
Sequence:
Chromosome: V; NC_003283.11 (6901681..6929038, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular dissection, tissue localization and Ca2+ binding of the ryanodine receptor of Caenorhabditis elegans. Hamada T, et al. J Mol Biol, 2002 Nov 15. PMID 12421563
  2. Slow Ca2+ dynamics in pharyngeal muscles in Caenorhabditis elegans during fast pumping. Shimozono S, et al. EMBO Rep, 2004 May. PMID 15088067, Free PMC Article
  3. Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation. Sun L, et al. J Neurosci, 2014 Nov 26. PMID 25429136, Free PMC Article
  4. unc-68 encodes a ryanodine receptor involved in regulating C. elegans body-wall muscle contraction. Maryon EB, et al. J Cell Biol, 1996 Aug. PMID 8769414, Free PMC Article
  5. Reactive oxygen species-mediated neurodegeneration is independent of the ryanodine receptor in Caernorhabditis elegans. Young LE, et al. J S C Acad Sci, 2015. PMID 27540332, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions.
    Title: Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions.
  2. Loss-of-function mutations of the ryanodine gene unc-68 (uncoordinated 68) essentially abolished large-amplitude miniature postsynaptic currents
    Title: Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in ligand-gated ion channel signaling pathway HEP PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ryanodine receptor
NP_001343688.1
  • Confirmed by transcript evidence
NP_001343689.1
  • Confirmed by transcript evidence
NP_001343695.1
  • Confirmed by transcript evidence
NP_001343696.1
  • Confirmed by transcript evidence
NP_001343808.1
  • Partially confirmed by transcript evidence
NP_001343809.1
  • Partially confirmed by transcript evidence
NP_001343810.1
  • Partially confirmed by transcript evidence
NP_001343811.1
  • Partially confirmed by transcript evidence
NP_001343812.1
  • Confirmed by transcript evidence
NP_001343813.1
  • Confirmed by transcript evidence
NP_001343814.1
  • Confirmed by transcript evidence
NP_001343815.1
  • Confirmed by transcript evidence
NP_001343816.1
  • Partially confirmed by transcript evidence
NP_001343817.1
  • Partially confirmed by transcript evidence
NP_001343818.1
  • Partially confirmed by transcript evidence
NP_001343819.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6901681..6929038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356679.3 → NP_001343688.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SNF8, P91905, Q94279
    Conserved Domains (11) summary
    cd00051
    Location:4320 → 4374
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4968 → 5110
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4661 → 4841
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4124 → 4237
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  2. NM_001356673.4 → NP_001343696.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAA7, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4190 → 4244
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4838 → 4980
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4531 → 4711
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3994 → 4107
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  3. NM_001356677.4 → NP_001343695.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAA6, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4306 → 4360
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4954 → 5096
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4647 → 4827
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4110 → 4223
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  4. NM_001356678.4 → NP_001343810.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3F1, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4307 → 4361
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4955 → 5097
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4648 → 4828
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4111 → 4224
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  5. NM_001356680.4 → NP_001343808.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3E8, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4321 → 4375
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4969 → 5111
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4662 → 4842
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4125 → 4238
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  6. NM_001356674.3 → NP_001343811.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C390, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4191 → 4245
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4839 → 4981
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4532 → 4712
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3995 → 4108
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  7. NM_001356675.3 → NP_001343689.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7WN66, G4SNF7, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4204 → 4258
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4852 → 4994
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4545 → 4725
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4008 → 4121
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  8. NM_001356676.3 → NP_001343809.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C354, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4205 → 4259
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:652 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1078 → 1210
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1542 → 1692
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4853 → 4995
    Ion_trans; Ion transport protein
    pfam01365
    Location:449 → 646
    RYDR_ITPR; RIH domain
    pfam02026
    Location:853 → 941
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4546 → 4726
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4009 → 4122
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:13 → 209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  9. NM_001356681.3 → NP_001343815.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C325, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4188 → 4242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4836 → 4978
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4529 → 4709
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3992 → 4105
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  10. NM_001356682.3 → NP_001343819.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C370, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4189 → 4243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4837 → 4979
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4530 → 4710
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3993 → 4106
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  11. NM_001356683.3 → NP_001343813.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3I4, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4202 → 4256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4850 → 4992
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4543 → 4723
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4006 → 4119
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  12. NM_001356684.3 → NP_001343817.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C388, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4203 → 4257
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4851 → 4993
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4544 → 4724
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4007 → 4120
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  13. NM_001356685.3 → NP_001343814.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2X2, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4304 → 4358
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4952 → 5094
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4645 → 4825
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4108 → 4221
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  14. NM_001356686.3 → NP_001343818.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3G1, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4305 → 4359
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4953 → 5095
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4646 → 4826
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4109 → 4222
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  15. NM_001356687.3 → NP_001343812.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3P6, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4318 → 4372
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4966 → 5108
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4659 → 4839
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4122 → 4235
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  16. NM_001356688.3 → NP_001343816.1  Ryanodine receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C384, P91905
    Conserved Domains (11) summary
    cd00051
    Location:4319 → 4373
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd12877
    Location:650 → 797
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1076 → 1208
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1540 → 1690
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4967 → 5109
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 644
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 939
    RyR; RyR domain
    pfam02815
    Location:218 → 397
    MIR; MIR domain
    pfam06459
    Location:4660 → 4840
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4123 → 4236
    RIH_assoc; RyR and IP3R Homology associated
    cl19745
    Location:19 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
Nucleotide Protein
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