air-1 Aurora kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: air-1
Official Full Name: Aurora kinase
Primary source: WormBase:WBGene00000098
Locus tag: CELE_K07C11.2
See related: AllianceGenome:WB:WBGene00000098
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine kinase activity. Involved in mitotic spindle assembly and positive regulation of protein localization to centrosome. Located in condensed nuclear chromosome and spindle. Is expressed in anterior distal tip cell; germ line; and posterior distal tip cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See air-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (8221488..8223582)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a Rho GEF, ECT-2, acts downstream of AIR-1 in regulating contractility and PAR-2 localisation, and AIR-1 depletion influences ECT-2 cortical localisation
Title: Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis in C. elegans embryos.
The authors demonstrate that AIR-1 prevents symmetry breaking early in the cell cycle, whereas centrosomal AIR-1 instructs polarity initiation thereafter.
Title: Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans.
Aurora A kinases and PP6 phosphatases have an ancient function in modulating spindle positioning, thus contributing to faithful cell division.
Title: Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.
human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A
Title: The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
AIR-1 has a kinase-dependent role at centrosomes and a kinase-independent role for stabilizing spindle microtubules and that coordination of these two roles is crucial for the assembly of mitotic spindles
Title: A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos.
Centrosomes serve to focus the Aurora A kinase AIR-1, which is essential for timely mitotic entry.Our findings support a model in which centrosomes serve as integrative centers for mitotic regulators and thus trigger mitotic entry in a timely fashion.
Title: Centrosomes promote timely mitotic entry in C. elegans embryos.
mitotic centrosomes generate a diffusible factor, which we propose is activated Aurora A, that promotes nuclear envelope breakdown (NEBD). A positive feedback loop, size may temporally couple centrosome maturation to NEBD during mitotic entry.
Title: A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.
alleles that affect postembryonic cell divisions and germline development
Title: Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07C11.2 (e-PCR)
- UniSTS:314638

K07C11.9 (e-PCR)
- UniSTS:312401

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in astral microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Aurora kinase

NP_505119.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8221488..8223582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072718.11 → NP_505119.1 Aurora kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505119.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDL3

Conserved Domains (1) summary

cd14007
Location:43 → 297

STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase