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Myo7b myosin VIIB [ Mus musculus (house mouse) ]

Gene ID: 17922, updated on 4-Jan-2025

Summary

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Official Symbol
Myo7bprovided by MGI
Official Full Name
myosin VIIBprovided by MGI
Primary source
MGI:MGI:107709
See related
Ensembl:ENSMUSG00000024388 AllianceGenome:MGI:107709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including actin filament organization; brush border assembly; and sensory perception of sound. Located in apical cytoplasm; brush border; and microvillus. Is expressed in genitourinary system and gut. Orthologous to human MYO7B (myosin VIIB). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in small intestine adult (RPKM 52.2), duodenum adult (RPKM 47.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Myo7b in Genome Data Viewer
Location:
18 B1; 18 17.89 cM
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32092287..32169984, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (31959234..32036931, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44150 Neighboring gene LIM and senescent cell antigen like domains 2 Neighboring gene predicted gene, 46619 Neighboring gene G protein-coupled receptor 17 Neighboring gene STARR-seq mESC enhancer starr_44152 Neighboring gene predicted gene 16344 Neighboring gene STARR-seq mESC enhancer starr_44153 Neighboring gene predicted gene, 35010 Neighboring gene IWS1, SUPT6 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vertebrate myosin VIIb is a high duty ratio motor adapted for generating and maintaining tension. Henn A, et al. J Biol Chem, 2005 Nov 25. PMID 16186105
  2. Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Chen ZY, et al. Genomics, 2001 Mar 15. PMID 11401444
  3. The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex. Choi MS, et al. J Biol Chem, 2020 Jul 10. PMID 32209652, Free PMC Article
  4. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Crawley SW, et al. Cell, 2014 Apr 10. PMID 24725409, Free PMC Article
  5. Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea. Durán Alonso MB, et al. Front Cell Dev Biol, 2021. PMID 34124068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloned, expressed and purified the catalytic motor domain, and characterized its actin-activated ATPase cycle
    Title: Vertebrate myosin VIIb is a high duty ratio motor adapted for generating and maintaining tension.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brush border assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in brush border assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unconventional myosin-VIIb
Names
myosin-VIIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032394.3 → NP_115770.2  unconventional myosin-VIIb

    See identical proteins and their annotated locations for NP_115770.2

    Status: VALIDATED

    Source sequence(s)
    AC131761, AK220152, BC138341
    Consensus CDS
    CCDS50244.1
    UniProtKB/Swiss-Prot
    B9EHR5, Q571N7, Q8R0U3, Q99MZ6
    Related
    ENSMUSP00000118046.2, ENSMUST00000134663.2
    Conserved Domains (9) summary
    smart00015
    Location:785 → 807
    IQ; Calmodulin-binding motif
    smart00139
    Location:1641 → 1788
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1797 → 2009
    B41; Band 4.1 homologues
    cd13198
    Location:1403 → 1499
    FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
    cd13199
    Location:2005 → 2100
    FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
    cd01381
    Location:79 → 748
    MYSc_Myo7; class VII myosin, motor domain
    cd17092
    Location:1193 → 1291
    FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
    cd17093
    Location:1795 → 1892
    FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
    cl17036
    Location:1500 → 1560
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32092287..32169984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MZ6.3 GenPept UniProtKB/Swiss-Prot:Q99MZ6

Gene LinkOut

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