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hsp-16.49 Heat shock protein Hsp-16.48/Hsp-16.49 [ Caenorhabditis elegans ]

Gene ID: 179288, updated on 9-Dec-2024

Summary

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Official Symbol
hsp-16.49
Official Full Name
Heat shock protein Hsp-16.48/Hsp-16.49
Primary source
WormBase:WBGene00002020
Locus tag
CELE_T27E4.9
See related
AllianceGenome:WB:WBGene00002020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hsp-16.49 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (9089280..9089766, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Heat shock protein Hsp-16.1/Hsp-16.11 Neighboring gene Heat shock protein Hsp-16.48/Hsp-16.49 Neighboring gene Heat shock protein Hsp-16.1/Hsp-16.11 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide. Link CD, et al. J Biol Chem, 2006 Jan 20. PMID 16239215
  2. Locus encoding a family of small heat shock genes in Caenorhabditis elegans: two genes duplicated to form a 3.8-kilobase inverted repeat. Russnak RH, et al. Mol Cell Biol, 1985 Jun. PMID 4033652, Free PMC Article
  3. Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans. Liu Y, et al. Biofactors, 2022 Mar. PMID 34580918
  4. Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans. Yu CW, et al. Chemosphere, 2016 May. PMID 26796881
  5. A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans. Guan S, et al. Free Radic Res, 2010 Jul. PMID 20528576

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in endoplasmic reticulum unfolded protein response IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
Heat shock protein Hsp-16.48/Hsp-16.49
NP_505356.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9089280..9089766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072955.3 → NP_505356.1  Heat shock protein Hsp-16.48/Hsp-16.49 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505356.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02513, Q27922
    Conserved Domains (2) summary
    cd06526
    Location:46 → 127
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    COG0071
    Location:46 → 138
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02513.1

Gene LinkOut

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