Myom1 myomesin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myom1provided by MGI
Official Full Name: myomesin 1provided by MGI
Primary source: MGI:MGI:1341430
See related: Ensembl:ENSMUSG00000024049 AllianceGenome:MGI:1341430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D430047A17Rik
Summary: Enables protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of protein secretion; protein kinase A signaling; and sarcomere organization. Predicted to act upstream of or within muscle contraction. Located in M band. Is expressed in several structures, including alimentary system; cardiovascular system; musculature; respiratory system; and skeleton. Orthologous to human MYOM1 (myomesin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 44.7), bladder adult (RPKM 18.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.3; 17 41.87 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (71326455..71433851)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (71003332..71126856)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Skelemin association with alphaIIbbeta3 integrin: a structural model.
Title: Skelemin association with αIIbβ3 integrin: a structural model.
ectopically expressed Myomesin-I was primarily targeted to the nucleus; presence of Myomesin-I in the nucleus led to the differential expression of more than 42 genes
Title: Nuclear localization of Myomesin-1: possible functions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myom1 (e-PCR), detects polymorphism
- UniSTS:536589

Myom1 (e-PCR), detects polymorphism
- UniSTS:239195

NoName (e-PCR)
- UniSTS:237691

27.MMHAP54FLA6.seq (e-PCR)
- UniSTS:123786

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in extraocular skeletal muscle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	IEA Inferred from Electronic Annotation more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myomesin-1

Names: myomesin family member 1; skelemin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083934.2 → NP_001077403.1 myomesin-1 isoform 2

See identical proteins and their annotated locations for NP_001077403.1

Status: VALIDATED

Source sequence(s)

AC154187, AC154218, AC154717

Consensus CDS

CCDS50176.1

UniProtKB/TrEMBL

Z4YJF5

Related

ENSMUSP00000136266.2, ENSMUST00000179759.3

Conserved Domains (3) summary

smart00409
Location:264 → 350

IG; Immunoglobulin

cd00063
Location:618 → 711

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:1456 → 1547

Ig; Immunoglobulin domain
NM_010867.3 → NP_034997.2 myomesin-1 isoform 1

See identical proteins and their annotated locations for NP_034997.2

Status: VALIDATED

Source sequence(s)

AC154187, AC154218, AC154717

Consensus CDS

CCDS37685.1

UniProtKB/Swiss-Prot

Q546T8, Q62234, Q6PAC0

UniProtKB/TrEMBL

Z4YJF5

Related

ENSMUSP00000072945.6, ENSMUST00000073211.13

Conserved Domains (3) summary

smart00410
Location:264 → 350

IG_like; Immunoglobulin like

cd00063
Location:618 → 711

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:1554 → 1645

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

71326455..71433851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523788.5 → XP_006523851.1 myomesin-1 isoform X3

Conserved Domains (3) summary

smart00409
Location:264 → 350

IG; Immunoglobulin

cd00063
Location:618 → 711

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:397 → 464

Ig; Immunoglobulin domain
XM_006523787.5 → XP_006523850.1 myomesin-1 isoform X2

Conserved Domains (3) summary

smart00409
Location:264 → 350

IG; Immunoglobulin

cd00063
Location:618 → 711

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:397 → 464

Ig; Immunoglobulin domain
XM_036160365.1 → XP_036016258.1 myomesin-1 isoform X1

Conserved Domains (3) summary

cd00063
Location:237 → 326

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:770 → 773

Ig; Ig strand A [structural motif]

cl11960
Location:770 → 861

Ig; Immunoglobulin domain