wdr-20 WD repeat-containing protein 20 homolog;WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wdr-20
Official Full Name: WD repeat-containing protein 20 homolog;WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00007428
Locus tag: CELE_C08B6.7
See related: AllianceGenome:WB:WBGene00007428
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in positive regulation of locomotion involved in locomotory behavior; positive regulation of macromolecule metabolic process; and positive regulation of protein localization to cell surface. Is expressed in head neurons; tail neurons; and ventral nerve cord. Orthologous to human DMWD (DM1 locus, WD repeat containing) and WDR20 (WD repeat domain 20). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See wdr-20 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (10130399..10134158, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The WD40-Repeat Protein WDR-20 and the Deubiquitinating Enzyme USP-46 Promote Cell Surface Levels of Glutamate Receptors.
Title: The WD40-Repeat Protein WDR-20 and the Deubiquitinating Enzyme USP-46 Promote Cell Surface Levels of Glutamate Receptors.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C08B6.7 (e-PCR)
- UniSTS:308997

C08B6.8 (e-PCR)
- UniSTS:321918

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein deubiquitination	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 20 homolog;WD_REPEATS_REGION domain-containing protein

NP_001335505.1

Confirmed by transcript evidence

NP_001368633.1

Partially confirmed by transcript evidence

NP_001370272.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10130399..10134158 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380736.2 → NP_001368633.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYT4

Conserved Domains (2) summary

sd00039
Location:229 → 266

7WD40; WD40 repeat [structural motif]

cl29593
Location:304 → 407

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001348580.4 → NP_001335505.1 WD repeat-containing protein 20 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

D9N129

Conserved Domains (2) summary

sd00039
Location:229 → 266

7WD40; WD40 repeat [structural motif]

cl25539
Location:304 → 407

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001383378.1 → NP_001370272.1 WD repeat-containing protein 20 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

D9N129, Q17818

Conserved Domains (2) summary

sd00039
Location:229 → 266

7WD40; WD40 repeat [structural motif]

cl29593
Location:304 → 407

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...