trx-2 Thioredoxin;putative thioredoxin-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: trx-2
Official Full Name: Thioredoxin;putative thioredoxin-2
Primary source: WormBase:WBGene00007099
Locus tag: CELE_B0024.9
See related: AllianceGenome:WB:WBGene00007099
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Located in mitochondrion. Is expressed in body wall musculature; head neurons; and vulval muscle. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trx-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (10314671..10315294)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants.
Title: Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants.
Suppression of the C. elegans thioredoxin orthologs trx-1 and trx-2, involved in the redox chaperone activity of exo-3, overrides the protective effect of cep-1 RNAi treatment on neuronal integrity, neuronal function, mean and maximum life span.
Title: Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0024.9 (e-PCR)
- UniSTS:320772

B0024.6 (e-PCR)
- UniSTS:307173

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Thioredoxin;putative thioredoxin-2

NP_001256207.1

Confirmed by transcript evidence

NP_001256208.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10314671..10315294

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269278.2 → NP_001256207.1 putative thioredoxin-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256207.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17424

Conserved Domains (1) summary

cd02947
Location:46 → 140

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
NM_001269279.3 → NP_001256208.1 Thioredoxin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256208.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MU08

Conserved Domains (1) summary

cd02947
Location:20 → 114

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...