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egl-9 Hypoxia-inducible factor prolyl hydroxylase [ Caenorhabditis elegans ]

Gene ID: 179461, updated on 9-Dec-2024

Summary

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Official Symbol
egl-9
Official Full Name
Hypoxia-inducible factor prolyl hydroxylase
Primary source
WormBase:WBGene00001178
Locus tag
CELE_F22E12.4
See related
AllianceGenome:WB:WBGene00001178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peptidyl-proline 4-dioxygenase activity. Involved in regulation of protein localization and response to hypoxia. Located in dendrite and nucleus. Is expressed in ventral nerve cord and vulval precursor cell. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to several human genes including EGLN1 (egl-9 family hypoxia inducible factor 1) and EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-9 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (10468517..10476915)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Cdc-42 Related Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa. Darby C, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611362, Free PMC Article
  2. Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning. Gallagher LA, et al. J Bacteriol, 2001 Nov. PMID 11591663, Free PMC Article
  3. Novel antimicrobial targets from combined pathogen and host genetics. Johnson CD, et al. Proc Natl Acad Sci U S A, 2000 Feb 1. PMID 10655466, Free PMC Article
  4. Characterization of gene expression associated with the adaptation of the nematode C. elegans to hypoxia and reoxygenation stress reveals an unexpected function of the neuroglobin GLB-5 in innate immunity. Zuckerman B, et al. Free Radic Biol Med, 2017 Jul. PMID 28495447
  5. Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system. Gan YH, et al. Mol Microbiol, 2002 Jun. PMID 12068805

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
    Title: Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
  2. study demonstrated that loss of egl-9, a negative regulator of HIF, confers HIF-dependent enhanced susceptibility to S. aureus while increasing resistance to Pseudomonas aeruginosa
    Title: EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.
  3. These data support a model in which SWAN-1, MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 fast killing.
    Title: C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
  4. Data show that EGL-9 inhibits HIF-1 transcriptional activity via a pathway that has little or no requirement for hydroxylase activity or for the EGL-9 MYND domain.
    Title: Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hypoxia-inducible factor-proline dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-proline 4-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-proline dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hypoxia-inducible factor prolyl hydroxylase
NP_001023833.1
  • Partially confirmed by transcript evidence
NP_001023834.1
  • Confirmed by transcript evidence
NP_001041105.1
  • Confirmed by transcript evidence
NP_001359645.1
  • Confirmed by transcript evidence
NP_741621.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10468517..10476915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028663.6 → NP_001023834.1  Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBV0
    Conserved Domains (2) summary
    smart00702
    Location:393 → 565
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam01753
    Location:39 → 79
    zf-MYND; MYND finger

  2. NM_171533.7 → NP_741621.1  Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741621.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBV0, G5ECV8, G5EE79, G5EEP8, Q56W01
    Conserved Domains (2) summary
    smart00702
    Location:393 → 565
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam01753
    Location:39 → 79
    zf-MYND; MYND finger

  3. NM_001373098.1 → NP_001359645.1  Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam01753
    Location:39 → 79
    zf-MYND; MYND finger

  4. NM_001047640.4 → NP_001041105.1  Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041105.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBV0
    Conserved Domains (1) summary
    smart00702
    Location:317 → 489
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  5. NM_001028662.4 → NP_001023833.1  Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023833.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBV0
    Conserved Domains (1) summary
    smart00702
    Location:135 → 307
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBV0.1

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