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scpl-4 Mitochondrial import inner membrane translocase subunit TIM50 [ Caenorhabditis elegans ]

Gene ID: 179481, updated on 9-Dec-2024

Summary

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Official Symbol
scpl-4
Official Full Name
Mitochondrial import inner membrane translocase subunit TIM50
Primary source
WormBase:WBGene00011897
Locus tag
CELE_T21C9.12
See related
AllianceGenome:WB:WBGene00011897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See scpl-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (10599104..10602146)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF4149 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glutaminyl-peptide cyclotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou S, et al. J Biol Chem, 2000 Jun 23. PMID 10777497
  2. A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Qadota H, et al. Mol Biol Cell, 2008 Jun. PMID 18337465, Free PMC Article
  3. Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans. Mitchell CJ, et al. Mol Oncol, 2016 Jun. PMID 27067626, Free PMC Article
  4. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
  5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial import inner membrane translocase subunit TIM50
NP_001360575.1
  • Confirmed by transcript evidence
NP_505722.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10599104..10602146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373099.3 → NP_001360575.1  Mitochondrial import inner membrane translocase subunit TIM50 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WU22
    Conserved Domains (1) summary
    pfam03031
    Location:247 → 395
    NIF; NLI interacting factor-like phosphatase

  2. NM_073321.7 → NP_505722.1  Mitochondrial import inner membrane translocase subunit TIM50 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22647
    Conserved Domains (1) summary
    pfam03031
    Location:248 → 396
    NIF; NLI interacting factor-like phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22647.1

Gene LinkOut

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