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H27A22.1 glutaminyl-peptide cyclotransferase [ Caenorhabditis elegans ]

Gene ID: 179482, updated on 4-Jan-2025

Summary

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Official Symbol
H27A22.1
Official Full Name
glutaminyl-peptide cyclotransferase
Primary source
WormBase:WBGene00010418
Locus tag
CELE_H27A22.1
See related
AllianceGenome:WB:WBGene00010418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Is expressed in head; hypodermis; pharynx; and tail. Orthologous to several human genes including QPCT (glutaminyl-peptide cyclotransferase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See H27A22.1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (10602555..10605581)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Mitochondrial import inner membrane translocase subunit TIM50 Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
  2. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutaminyl-peptide cyclotransferase
NP_001041143.1
  • Confirmed by transcript evidence
NP_001041144.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10602555..10605581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047679.5 → NP_001041144.1  glutaminyl-peptide cyclotransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041144.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBT9
    Conserved Domains (1) summary
    cd03880
    Location:50 → 350
    M28_QC_like; M28 Zn-peptidase glutaminyl cyclase

  2. NM_001047678.6 → NP_001041143.1  glutaminyl-peptide cyclotransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041143.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF46
    Conserved Domains (1) summary
    cd03880
    Location:36 → 336
    M28_QC_like; M28 Zn-peptidase glutaminyl cyclase
Nucleotide Protein
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