tut-2 Cytoplasmic tRNA 2-thiolation protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tut-2
Official Full Name: Cytoplasmic tRNA 2-thiolation protein 2
Primary source: WormBase:WBGene00009256
Locus tag: CELE_F29F11.3
See related: AllianceGenome:WB:WBGene00009256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tut-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (10658235..10659658)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

inactivation of the complex leads to loss of thiolation on tRNAs and to a thermosensitive decrease of viability associated with marked ploidy abnormalities and aberrant development
Title: The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F29F11.3 (e-PCR)
- UniSTS:306594

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein urmylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA thio-modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA thio-modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble uridine modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Cytoplasmic tRNA 2-thiolation protein 2

NP_505729.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10658235..10659658

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073328.8 → NP_505729.1 Cytoplasmic tRNA 2-thiolation protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505729.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19906

Conserved Domains (1) summary

pfam10288
Location:276 → 323

CTU2; Cytoplasmic tRNA 2-thiolation protein 2