hmp-1 Alpha-catenin-like protein hmp-1;Vinculin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmp-1
Official Full Name: Alpha-catenin-like protein hmp-1;Vinculin
Primary source: WormBase:WBGene00001978
Locus tag: CELE_R13H4.4
See related: AllianceGenome:WB:WBGene00001978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity and beta-catenin binding activity. Involved in several processes, including cortical actin cytoskeleton organization; embryonic morphogenesis; and regulation of actin cytoskeleton organization. Located in adherens junction and apical junction complex. Part of catenin complex. Is expressed in several structures, including germ cell; intestinal cell; neuroblasts; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13; complex cortical dysplasia with other brain malformations; and patterned macular dystrophy 2. Orthologous to several human genes including CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hmp-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (11845871..11852166)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction.
Title: Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction.
The nematode alpha-catenin ortholog, HMP1, has an extended alpha-helix when bound to actin filaments.
Title: The nematode α-catenin ortholog, HMP1, has an extended α-helix when bound to actin filaments.
data indicate that HMP-1 does not modulate HMR-1/E-cadherin turnover, is required to recruit junctional actin but not stress fiber-like actin bundles.
Title: HMP-1/α-catenin promotes junctional mechanical integrity during morphogenesis.
Deletion analysis based on the crystal structure shows that the first helix of HMP-1 is necessary for binding HMP-2 avidly in vitro and for efficient recruitment of HMP-1 to adherens junctions in embryos. HMP-2 Ser-47 and Tyr-69 flank its binding interface with HMP-1, and we show that phosphomimetic mutations at these two sites decrease binding affinity of HMP-1 to HMP-2 by 40-100-fold
Title: Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β-catenin-binding interface.
HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex.
Title: Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin.
Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/alpha-catenin modulate F-actin binding independently of vinculin
Title: Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin.
In vitro, UNC-94 acts in combination with HMP-1, leading to longer actin bundles than with HMP-1 alone.
Title: Tropomodulin protects α-catenin-dependent junctional-actin networks under stress during epithelial morphogenesis.
Data suggest that HMP-1 is auto-inhibited
Title: In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13H4.4 (e-PCR)
- UniSTS:307880

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Alpha-catenin-like protein hmp-1;Vinculin

NP_001122991.1

Confirmed by transcript evidence

NP_001256379.1

Confirmed by transcript evidence

NP_001263866.1

Confirmed by transcript evidence

NP_001360176.1

Confirmed by transcript evidence

NP_001370891.1

Confirmed by transcript evidence

NP_505985.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11845871..11852166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373121.3 → NP_001360176.1 Vinculin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

I7K4K5

Conserved Domains (1) summary

pfam01044
Location:15 → 848

Vinculin; Vinculin family
NM_001129519.3 → NP_001122991.1 Vinculin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122991.1

Status: REVIEWED

UniProtKB/TrEMBL

A5JYX3

Conserved Domains (1) summary

pfam01044
Location:77 → 869

Vinculin; Vinculin family
NM_073584.7 → NP_505985.1 Alpha-catenin-like protein hmp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90947

Conserved Domains (1) summary

pfam01044
Location:77 → 869

Vinculin; Vinculin family
NM_001383414.1 → NP_001370891.1 Vinculin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

I7J4D2

Conserved Domains (1) summary

pfam01044
Location:77 → 855

Vinculin; Vinculin family
NM_001276937.3 → NP_001263866.1 Vinculin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263866.1

Status: REVIEWED

UniProtKB/TrEMBL

I7LFF2

Conserved Domains (1) summary

pfam01044
Location:77 → 848

Vinculin; Vinculin family
NM_001269450.3 → NP_001256379.1 Alpha-catenin-like protein hmp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256379.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUG3