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pkc-1 Protein kinase C;Protein kinase C-like 1B [ Caenorhabditis elegans ]

Gene ID: 179649, updated on 4-Jan-2025

Summary

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Official Symbol
pkc-1
Official Full Name
Protein kinase C;Protein kinase C-like 1B
Primary source
WormBase:WBGene00004032
Locus tag
CELE_F57F5.5
See related
AllianceGenome:WB:WBGene00004032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including insulin-like growth factor receptor signaling pathway; regulated exocytosis; and regulation of presynaptic dense core granule exocytosis. Located in cholinergic synapse and neuron projection. Is expressed in ganglia; linker cell; and neurons. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to several human genes including PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pkc-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (12014385..12032131, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ABC transmembrane type-1 domain-containing protein Neighboring gene Adducin-related protein 2;Class II aldolase/adducin N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Sulfatase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kup-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons. Luo L, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550307, Free PMC Article
  2. High concentration of vitamin E decreases thermosensation and thermotaxis learning and the underlying mechanisms in the nematode Caenorhabditis elegans. Li Y, et al. PLoS One, 2013. PMID 23951104, Free PMC Article
  3. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration. Liachko NF, et al. Ann Neurol, 2013 Jul. PMID 23424178, Free PMC Article
  4. Sensorimotor control during isothermal tracking in Caenorhabditis elegans. Luo L, et al. J Exp Biol, 2006 Dec. PMID 17114399
  5. The redundancy and diversity between two novel PKC isotypes that regulate learning in Caenorhabditis elegans. Hiroki S, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35027448, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dense core granule exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of response to drug IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of presynaptic dense core granule exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynaptic dense core granule exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to salt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of chemical stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of chemical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cholinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cholinergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein kinase C;Protein kinase C-like 1B
NP_001256394.1
  • Confirmed by transcript evidence
NP_001256395.1
  • Confirmed by transcript evidence
NP_001256396.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12014385..12032131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269466.4 → NP_001256395.1  Protein kinase C-like 1B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256395.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G3MU31, P34885, Q20953
    Conserved Domains (4) summary
    cd04014
    Location:3 → 132
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:378 → 638
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:382 → 702
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:249 → 301
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. NM_001269465.2 → NP_001256394.1  Protein kinase C-like 1B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256394.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34885
    Conserved Domains (3) summary
    smart00220
    Location:291 → 551
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:295 → 615
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:162 → 214
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. NM_001269467.3 → NP_001256396.1  Protein kinase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256396.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2Y7
    Conserved Domains (4) summary
    cd04014
    Location:59 → 188
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:434 → 694
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:438 → 758
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:305 → 357
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34885.2

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