che-11 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: che-11
Official Full Name: WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00000490
Locus tag: CELE_C27A7.4
See related: AllianceGenome:WB:WBGene00000490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including dauer entry; determination of adult lifespan; and positive regulation of intracellular transport. Located in non-motile cilium. Is expressed in body wall musculature; head; and neurons. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of intraciliary anterograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intraciliary retrograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle A	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle A	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

NP_506047.5

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