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vab-8 Kinesin-like protein vab-8 [ Caenorhabditis elegans ]

Gene ID: 179675, updated on 4-Jan-2025

Summary

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Official Symbol
vab-8
Official Full Name
Kinesin-like protein vab-8
Primary source
WormBase:WBGene00006874
Locus tag
CELE_K12F2.2
See related
AllianceGenome:WB:WBGene00006874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including egg-laying behavior; generation of neurons; and negative regulation of motor neuron migration. Located in striated muscle thin filament. Is expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A) and KIF26B (kinesin family member 26B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See vab-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (12213327..12225934)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Myosin-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurexin and frizzled intercept axonal transport at microtubule minus ends to control synapse formation. Balseiro-Gómez S, et al. Dev Cell, 2022 Aug 8. PMID 35809561, Free PMC Article
  2. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Lai T, et al. Development, 2004 Dec. PMID 15539493
  3. Receptors on neurons help shape worm development. Robinson R. PLoS Biol, 2013. PMID 23319890, Free PMC Article
  4. Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system. Mardick JI, et al. Dev Biol, 2021 Sep. PMID 33991533, Free PMC Article
  5. vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity. Wolf FW, et al. Neuron, 1998 Apr. PMID 9581759

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics
    Title: Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
  2. VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth
    Title: The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
  3. VAB-8L directs cell and growth-cone migrations by promoting localization of guidance receptors to the cell surface.
    Title: C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of motor neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Kinesin-like protein vab-8
NP_001122977.1
  • Confirmed by transcript evidence
NP_506063.2
  • Confirmed by transcript evidence
NP_506064.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12213327..12225934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073662.7 → NP_506063.2  Kinesin-like protein vab-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506063.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21441, Q9TVW0, Q9U541
    Conserved Domains (1) summary
    cl22853
    Location:54 → 300
    Motor_domain; Myosin and Kinesin motor domain

  2. NM_001129505.5 → NP_001122977.1  Kinesin-like protein vab-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ45

  3. NM_073663.6 → NP_506064.1  Kinesin-like protein vab-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506064.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21441
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21441.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.