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srpa-68 Signal recognition particle subunit SRP68 [ Caenorhabditis elegans ]

Gene ID: 179686, updated on 9-Dec-2024

Summary

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Official Symbol
srpa-68
Official Full Name
Signal recognition particle subunit SRP68
Primary source
WormBase:WBGene00010097
Locus tag
CELE_F55C5.8
See related
AllianceGenome:WB:WBGene00010097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in body wall musculature; intestine; non-striated muscle; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Orthologous to human SRP68 (signal recognition particle 68). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See srpa-68 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (12288922..12291658, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene PX domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
  2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endoplasmic reticulum signal peptide binding IEA
Inferred from Electronic Annotation
more info
  
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal recognition particle binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Signal recognition particle subunit SRP68
NP_506083.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12288922..12291658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073682.7 → NP_506083.1  Signal recognition particle subunit SRP68 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506083.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20822
    Conserved Domains (1) summary
    cl22422
    Location:35 → 556
    SRP68-RBD; RNA-binding domain of signal recognition particle subunit 68
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20822.2

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