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sqt-3 Collagen triple helix repeat protein;Cuticle collagen 1 [ Caenorhabditis elegans ]

Gene ID: 179693, updated on 2-Nov-2024

Summary

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Official Symbol
sqt-3
Official Full Name
Collagen triple helix repeat protein;Cuticle collagen 1
Primary source
WormBase:WBGene00005018
Locus tag
CELE_F23H12.4
See related
AllianceGenome:WB:WBGene00005018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sqt-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (12352745..12354320)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene V-SNARE coiled-coil homology domain-containing protein Neighboring gene IncG Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans sqt-3 mutants have mutations in the col-1 collagen gene. van der Keyl H, et al. Dev Dyn, 1994 Sep. PMID 7803850
  2. Caenorhabditis elegans morphogenesis: the role of the cytoskeleton in elongation of the embryo. Priess JR, et al. Dev Biol, 1986 Sep. PMID 3743895
  3. Haemonchus contortus: evidence that the 3A3 collagen gene is a member of an evolutionarily conserved family of nematode cuticle collagens. Cox GN, et al. Exp Parasitol, 1990 Feb. PMID 2404780
  4. Expression of chimeric genes in Caenorhabditis elegans. Jefferson RA, et al. J Mol Biol, 1987 Jan 5. PMID 3295256
  5. Structure and expression of Ascaris suum collagen genes: a comparison with Caenorhabditis elegans. Kingston IB, et al. Acta Trop, 1990 Jul. PMID 1978528

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the roles of dpy-31, sqt-3, and dpy-17 in nematode collagen assembly
    Title: The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
  2. Suppressor of DPY-31. rol-4 is synonym.
    Title: Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cuticle NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen and cuticulin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen and cuticulin-based cuticle development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen and cuticulin-based cuticle extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Collagen triple helix repeat protein;Cuticle collagen 1
NP_001256412.1
  • Confirmed by transcript evidence
NP_001256413.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12352745..12354320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269483.3 → NP_001256412.1  Cuticle collagen 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256412.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08124, Q19763
    Conserved Domains (1) summary
    smart01088
    Location:12 → 64
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain

  2. NM_001269484.3 → NP_001256413.1  Collagen triple helix repeat protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256413.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2C4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08124.2

Gene LinkOut

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