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lgmn-1 legumain [ Caenorhabditis elegans ]

Gene ID: 179714, updated on 4-Jan-2025

Summary

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Official Symbol
lgmn-1
Official Full Name
legumain
Primary source
WormBase:WBGene00012144
Locus tag
CELE_T28H10.3
See related
AllianceGenome:WB:WBGene00012144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in vacuole. Orthologous to human LGMN (legumain). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lgmn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (12513056..12514941)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene Calmodulin-like protein;EF-hand domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. Xia Y, et al. Sci Adv, 2022 Apr. PMID 35353567, Free PMC Article
  2. Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity. Yu Y, et al. Elife, 2024 Jan 19. PMID 38240316, Free PMC Article
  3. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  4. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response HEP PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
legumain
NP_506137.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12513056..12514941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073736.7 → NP_506137.1  legumain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBF4
    Conserved Domains (1) summary
    pfam01650
    Location:44 → 300
    Peptidase_C13; Peptidase C13 family
Nucleotide Protein
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