cubn-1 Cubilin homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cubn-1
Official Full Name: Cubilin homolog
Primary source: WormBase:WBGene00013855
Locus tag: CELE_ZC116.3
See related: AllianceGenome:WB:WBGene00013855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in lipid metabolic process and protein transport. Predicted to be located in extracellular region. Is expressed in hypodermis; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cubn-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 42

Sequence:: Chromosome: V; NC_003283.11 (12611329..12628749)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC116.2 (e-PCR)
- UniSTS:321097

ZC116.3 (e-PCR)
- UniSTS:308204

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cubilin homolog

NP_506157.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12611329..12628749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073756.7 → NP_506157.3 Cubilin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506157.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20911, Q23242

Conserved Domains (7) summary

smart00042
Location:2482 → 2585

CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein

smart00179
Location:306 → 345

EGF_CA; Calcium-binding EGF-like domain

cd00041
Location:1065 → 1181

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:207 → 248

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:480 → 509

EGF; EGF-like domain

pfam12947
Location:392 → 429

EGF_3; EGF domain

cl00049
Location:1210 → 1297

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.