dhs-21 L-xylulose reductase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dhs-21
Official Full Name: L-xylulose reductase
Primary source: WormBase:WBGene00000984
Locus tag: CELE_R11D1.11
See related: AllianceGenome:WB:WBGene00000984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables L-xylulose reductase (NADPH) activity and carbonyl reductase (NADPH) activity. Involved in xylulose catabolic process. Located in plasma membrane. Is expressed in hermaphrodite gonad; hypodermis; and intestine. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dhs-21 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (12731767..12733645, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that DHS-21 is a bona fide DCXR of C. elegans, essential for normal life span and reproduction.
Title: DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C15C8.1 (e-PCR)
- UniSTS:309080

R11D1.11 (e-PCR)
- UniSTS:314795

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-xylulose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-xylulose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-xylulose reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables L-xylulose reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-xylose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xylulose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xylulose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xylulose metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: L-xylulose reductase

NP_506182.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12731767..12733645 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073781.8 → NP_506182.2 L-xylulose reductase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506182.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21929, Q27GP8

Conserved Domains (2) summary

PRK07060
Location:1 → 249

PRK07060; short chain dehydrogenase; Provisional

cd05351
Location:3 → 251

XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs