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anp-1 Aminopeptidase [ Caenorhabditis elegans ]

Gene ID: 179763, updated on 2-Nov-2024

Summary

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Official Symbol
anp-1
Official Full Name
Aminopeptidase
Primary source
WormBase:WBGene00011587
Locus tag
CELE_T07F10.1
See related
AllianceGenome:WB:WBGene00011587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables metalloaminopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in excretory cell; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to several human genes including ANPEP (alanyl aminopeptidase, membrane); ERAP1 (endoplasmic reticulum aminopeptidase 1); and ERAP2 (endoplasmic reticulum aminopeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See anp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
14
Sequence:
Chromosome: V; NC_003283.11 (12859444..12863837)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein;Transmembrane protein Neighboring gene DUF19 domain-containing protein Neighboring gene BRCT domain-containing protein Neighboring gene RRM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans. Su S, et al. PeerJ, 2019. PMID 31737443, Free PMC Article
  2. Assessment of Caenorhabditis elegans as a model in Haemonchus contortus vaccine research. Geldhof P, et al. Mol Biochem Parasitol, 2007 Apr. PMID 17234278
  3. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Mohandas N, et al. Biotechnol Adv, 2016 Mar-Apr. PMID 26597954
  4. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article
  5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aminopeptidase
NP_001041160.1
  • Confirmed by transcript evidence
NP_001041161.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12859444..12863837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047695.5 → NP_001041160.1  Aminopeptidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041160.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22317
    Conserved Domains (3) summary
    cd09601
    Location:93 → 559
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:85 → 486
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:632 → 964
    ERAP1_C; ERAP1-like C-terminal domain

  2. NM_001047696.3 → NP_001041161.1  Aminopeptidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1HB04
    Conserved Domains (3) summary
    cd09601
    Location:81 → 547
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:73 → 474
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:620 → 952
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein
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