Ncoa3 nuclear receptor coactivator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncoa3provided by MGI
Official Full Name: nuclear receptor coactivator 3provided by MGI
Primary source: MGI:MGI:1276535
See related: Ensembl:ENSMUSG00000027678 AllianceGenome:MGI:1276535
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Actr; Aib1; Rac3; Src3; pCip; Tram1; p/Cip; KAT13B; Tram-1; bHLHe42; 2010305B15Rik
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II complex binding activity; and nuclear receptor coactivator activity. Involved in cell dedifferentiation; positive regulation of stem cell population maintenance; and regulation of stem cell division. Acts upstream of or within several processes, including labyrinthine layer morphogenesis; mammary gland branching involved in thelarche; and negative regulation of stem cell differentiation. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 20.4), thymus adult (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 86.22 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (165834557..165915162)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (165992637..166073242)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy.
Title: Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy.
Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis.
Title: Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis.
Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion.
Title: Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion.
NCoA3 upregulation in breast cancer-associated adipocytes elicits an inflammatory profile.
Title: NCoA3 upregulation in breast cancer‑associated adipocytes elicits an inflammatory profile.
Nuclear receptor coactivator 3 transactivates proinflammatory cytokines in collagen-induced arthritis.
Title: Nuclear receptor coactivator 3 transactivates proinflammatory cytokines in collagen-induced arthritis.
Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment.
Title: Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment.
SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment.
Title: SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment.
SRC3 deficiency exacerbates lipopolysaccharide-induced acute respiratory distress syndrome in mice.
Title: SRC3 deficiency exacerbates lipopolysaccharide-induced acute respiratory distress syndrome in mice.
Aib1 deficiency exacerbates inflammatory responses in acute myocardial infarction mice.
Title: Aib1 deficiency exacerbates inflammatory responses in acute myocardial infarction mice.
SRC-3 Knockout Attenuates Myocardial Injury Induced by Chronic Intermittent Hypoxia in Mice.
Title: SRC-3 Knockout Attenuates Myocardial Injury Induced by Chronic Intermittent Hypoxia in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC17613P1 (e-PCR)
- UniSTS:271639

SHGC-152427 (e-PCR)
- UniSTS:182584

PMC113761P3 (e-PCR)
- UniSTS:270254

AW321064 (e-PCR)
- UniSTS:185518

Ncoa3 (e-PCR), detects polymorphism
- UniSTS:479179

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within labyrinthine layer morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in thelarche	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor coactivator 3

Names: AIB-1; CBP-interacting protein; NCoA-3; RAC-3; SRC-3; amplified in breast cancer-1 protein homolog; receptor-associated coactivator 3; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1

NP_001361708.1

EC 2.3.1.48

NP_001392089.1

EC 2.3.1.48

NP_001392090.1

EC 2.3.1.48

NP_032705.2

EC 2.3.1.48

XP_030104100.1

EC 2.3.1.48

XP_036015065.1

EC 2.3.1.48

XP_036015066.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374779.1 → NP_001361708.1 nuclear receptor coactivator 3 isoform 2

Status: VALIDATED

Source sequence(s)

AL589873, AL589902

Consensus CDS

CCDS89586.1

UniProtKB/TrEMBL

A2A468, Q3UQL7

Related

ENSMUSP00000104875.2, ENSMUST00000109252.9

Conserved Domains (9) summary

smart00091
Location:117 → 172

PAS; PAS domain

pfam08815
Location:1056 → 1103

Nuc_rec_co-act; Nuclear receptor coactivator

pfam09606
Location:1094 → 1397

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam07469
Location:1269 → 1325

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:608 → 696

SRC-1; Steroid receptor coactivator

pfam14598
Location:262 → 372

PAS_11; PAS domain

pfam16279
Location:714 → 801

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:451 → 564

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

cl00081
Location:33 → 102

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_001405160.1 → NP_001392089.1 nuclear receptor coactivator 3 isoform 3

Status: VALIDATED

Source sequence(s)

AL589873, AL589902
NM_001405161.1 → NP_001392090.1 nuclear receptor coactivator 3 isoform 4

Status: VALIDATED

Source sequence(s)

AL589873, AL589902
NM_008679.4 → NP_032705.2 nuclear receptor coactivator 3 isoform 1

See identical proteins and their annotated locations for NP_032705.2

Status: VALIDATED

Source sequence(s)

AL589873, AL589902

Consensus CDS

CCDS38333.1

UniProtKB/TrEMBL

Q05BA5, Q3UQL7

Related

ENSMUSP00000085416.6, ENSMUST00000088095.7

Conserved Domains (9) summary

smart00091
Location:117 → 172

PAS; PAS domain

pfam08815
Location:1056 → 1103

Nuc_rec_co-act; Nuclear receptor coactivator

pfam09606
Location:1094 → 1398

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam07469
Location:1270 → 1326

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:608 → 696

SRC-1; Steroid receptor coactivator

pfam14598
Location:262 → 372

PAS_11; PAS domain

pfam16279
Location:714 → 801

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:451 → 564

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

cl00081
Location:33 → 102

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

165834557..165915162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159172.1 → XP_036015065.1 nuclear receptor coactivator 3 isoform X1

UniProtKB/TrEMBL

A5D6Q2

Conserved Domains (8) summary

TIGR01628
Location:1115 → 1283

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00091
Location:3 → 54

PAS; PAS domain

pfam07469
Location:1152 → 1209

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:938 → 984

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:490 → 578

SRC-1; Steroid receptor coactivator

pfam14598
Location:144 → 254

PAS_11; PAS domain

pfam16279
Location:596 → 683

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:333 → 446

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_030248240.2 → XP_030104100.1 nuclear receptor coactivator 3 isoform X3

UniProtKB/TrEMBL

A5D6Q2

Conserved Domains (7) summary

pfam08815
Location:857 → 904

Nuc_rec_co-act; Nuclear receptor coactivator

pfam09606
Location:895 → 1199

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam07469
Location:1071 → 1127

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:409 → 497

SRC-1; Steroid receptor coactivator

pfam14598
Location:63 → 173

PAS_11; PAS domain

pfam16279
Location:515 → 602

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:252 → 365

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_036159173.1 → XP_036015066.1 nuclear receptor coactivator 3 isoform X1

UniProtKB/TrEMBL

A5D6Q2

Conserved Domains (8) summary

TIGR01628
Location:1115 → 1283

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00091
Location:3 → 54

PAS; PAS domain

pfam07469
Location:1152 → 1209

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:938 → 984

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:490 → 578

SRC-1; Steroid receptor coactivator

pfam14598
Location:144 → 254

PAS_11; PAS domain

pfam16279
Location:596 → 683

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:333 → 446

NCOA_u2; Unstructured region on nuclear receptor coactivator protein