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avr-15 Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179834, updated on 4-Jan-2025

Summary

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Official Symbol
avr-15
Official Full Name
Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein
Primary source
WormBase:WBGene00000233
Locus tag
CELE_R11G10.1
See related
AllianceGenome:WB:WBGene00000233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity. Predicted to contribute to chloride channel activity. Involved in action potential; locomotion involved in locomotory behavior; and regulation of nematode pharyngeal pumping. Predicted to be located in plasma membrane and postsynapse. Is expressed in motor neurons; pharynx; preanal ganglion neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in hyperekplexia 2 and syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA2 (glycine receptor alpha 2); GLRA3 (glycine receptor alpha 3); and GLRB (glycine receptor beta). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See avr-15 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (13498780..13511718, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Abnormal cell migration protein 18-like fibronectin type I domain-containing protein Neighboring gene FYVE-type domain-containing protein Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene tRNA-Pro Neighboring gene tRNA-Pro Neighboring gene Putative selenium-binding protein Neighboring gene Serpentine Receptor, class Z Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glutamate-gated Cl- channels in Caenorhabditis elegans and parasitic nematodes. Wolstenholme AJ. Biochem Soc Trans, 1997 Aug. PMID 9388555
  2. Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native receptor. Pemberton DJ, et al. Mol Pharmacol, 2001 May. PMID 11306685
  3. Effect of refrigeration on the antinematodal efficacy of ivermectin. O'Lone RB, et al. J Parasitol, 2001 Apr. PMID 11318586
  4. The Validation of Nematode-Specific Acetylcholine-Gated Chloride Channels as Potential Anthelmintic Drug Targets. Wever CM, et al. PLoS One, 2015. PMID 26393923, Free PMC Article
  5. Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans. Shaver AO, et al. PLoS Pathog, 2024 May. PMID 38768235, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein
NP_001024076.1
  • Confirmed by transcript evidence
NP_001024077.1
  • Confirmed by transcript evidence
NP_001256513.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13498780..13511718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028905.8 → NP_001024076.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECH3, O17547
    Conserved Domains (1) summary
    TIGR00860
    Location:253 → 648
    LIC; Cation transporter family protein

  2. NM_001028906.6 → NP_001024077.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024077.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17548, Q95PJ6
    Conserved Domains (1) summary
    TIGR00860
    Location:74 → 469
    LIC; Cation transporter family protein

  3. NM_001269584.3 → NP_001256513.1  Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256513.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D7SFP2
    Conserved Domains (1) summary
    cd19062
    Location:1 → 170
    LGIC_TM_GluCl; transmembrane domain of glutamate gated chloride channel (GluCl)
Nucleotide Protein
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