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swan-2 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179875, updated on 4-Jan-2025

Summary

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Official Symbol
swan-2
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00009976
Locus tag
CELE_F53C11.7
See related
AllianceGenome:WB:WBGene00009976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in response to heat and response to osmotic stress. Predicted to be active in nucleus. Is expressed in head; intestine; nervous system; non-striated muscle; and reproductive system. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See swan-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (13800976..13804281, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene USP domain-containing protein;Zf-C3H1 domain-containing protein Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Yang Y, et al. Genetics, 2006 Dec. PMID 16980389, Free PMC Article
  2. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. Ritterhoff S, et al. EMBO J, 2010 Nov 17. PMID 20940704, Free PMC Article
  3. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Kim Y, et al. Genes Dev, 2008 Sep 15. PMID 18794348, Free PMC Article
  4. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Mehta R, et al. Science, 2009 May 29. PMID 19372390, Free PMC Article
  5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to osmotic stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_506417.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13800976..13804281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074016.9 → NP_506417.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506417.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93759
    Conserved Domains (2) summary
    sd00039
    Location:156 → 199
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:149 → 431
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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