hpx-2 Heme peroxidase 2 light chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hpx-2
Official Full Name: Heme peroxidase 2 light chain
Primary source: WormBase:WBGene00008627
Locus tag: CELE_F09F3.5
See related: AllianceGenome:WB:WBGene00008627
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peroxidase activity. Involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Is expressed in gland cell and hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hpx-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (13850470..13853199)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hpx-2 mutant animals possessed a weaker cuticle structure, indicated by higher permeability to a DNA dye, but exhibited no obvious morphological defects. In addition, fluorescent labeling of HPX-2 revealed its expression in the pharynx, an organ in which BLI-3 is also present. Interestingly, loss of HPX-2 increased intestinal colonization of E. faecalis, suggesting its role in the pharynx may limit intestinal colonization
Title: Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogens.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09F3.4 (e-PCR)
- UniSTS:315682

F09F3.5 (e-PCR)
- UniSTS:307445

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Heme peroxidase 2 light chain

NP_506432.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13850470..13853199

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074031.4 → NP_506432.1 Heme peroxidase 2 light chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506432.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90820

Conserved Domains (1) summary

pfam03098
Location:158 → 696

An_peroxidase; Animal haem peroxidase