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nep-21 Neprilysin-2;Neprilysin-21 [ Caenorhabditis elegans ]

Gene ID: 179925, updated on 2-Nov-2024

Summary

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Official Symbol
nep-21
Official Full Name
Neprilysin-2;Neprilysin-21
Primary source
WormBase:WBGene00011794
Locus tag
CELE_T16A9.4
See related
AllianceGenome:WB:WBGene00011794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in accessory cell; anterior ganglion; lumbar ganglion; motor neurons; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nep-21 in Genome Data Viewer
Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (14215339..14226473, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Membrane transporter protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenic reporter analysis of ChIP-Seq-defined enhancers identifies novel target genes for the terminal selector UNC-3/Collier/Ebf. Li Y, et al. MicroPubl Biol, 2021. PMID 34549172, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Neprilysin-2;Neprilysin-21
NP_001263884.1
  • Confirmed by transcript evidence
NP_001343820.1
  • Confirmed by transcript evidence
NP_001360525.1
  • Confirmed by transcript evidence
NP_506520.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14215339..14226473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276955.4 → NP_001263884.1  Neprilysin-21 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7S146
    Conserved Domains (2) summary
    cd08662
    Location:106 → 775
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:95 → 777
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

  2. NM_001356755.4 → NP_001343820.1  Neprilysin-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3G3
    Conserved Domains (1) summary
    cd08662
    Location:193 → 854
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

  3. NM_001373156.2 → NP_001360525.1  Neprilysin-21 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WVJ1
    Conserved Domains (1) summary
    cd08662
    Location:193 → 862
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

  4. NM_074119.8 → NP_506520.1  Neprilysin-21 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22523
    Conserved Domains (2) summary
    cd08662
    Location:106 → 767
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:95 → 769
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22523.2

Gene LinkOut

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