glc-1 Glutamate-gated chloride channel alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glc-1
Official Full Name: Glutamate-gated chloride channel alpha
Primary source: WormBase:WBGene00001591
Locus tag: CELE_F11A5.10
See related: AllianceGenome:WB:WBGene00001591
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables extracellularly glutamate-gated chloride channel activity; glutamate binding activity; and identical protein binding activity. Involved in chloride transmembrane transport; locomotion involved in locomotory behavior; and protein complex oligomerization. Located in plasma membrane. Is expressed in body wall musculature; head neurons; intestine; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Orthologous to several human genes including GLRA2 (glycine receptor alpha 2) and GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See glc-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (16219634..16221917)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

present the first three-dimensional structure of an inhibitory anion-selective Cys-loop receptor, the homopentameric Caenorhabditis elegans glutamate-gated chloride channel alpha at 3.3 A resolution [glutamate-gated chloride channel alpha]
Title: Principles of activation and permeation in an anion-selective Cys-loop receptor.
findings show that a naturally occurring four-amino-acid deletion in the ligand-binding domain of GLC-1, the alpha-subunit of a glutamate-gated chloride channel, confers resistance to avermectins in Caenorhabditis elegans
Title: Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F11A5.10 (e-PCR)
- UniSTS:321355

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glutamate-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glutamate-gated chloride channel alpha

NP_507090.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16219634..16221917

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074689.7 → NP_507090.1 Glutamate-gated chloride channel alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507090.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBR3

Conserved Domains (3) summary

TIGR00860
Location:65 → 452

LIC; Cation transporter family protein

pfam02931
Location:64 → 273

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:281 → 451

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region