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skr-5 Skp1-related protein [ Caenorhabditis elegans ]

Gene ID: 180148, updated on 9-Dec-2024

Summary

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Official Symbol
skr-5
Official Full Name
Skp1-related protein
Primary source
WormBase:WBGene00004811
Locus tag
CELE_F47H4.10
See related
AllianceGenome:WB:WBGene00004811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cullin family protein binding activity. Involved in determination of adult lifespan. Predicted to be active in cytoplasm and nucleus. Is expressed in hypodermis; intestine; and vulval muscle. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See skr-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (17347902..17348723)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Zinc finger protein lsy-27 Neighboring gene DUF38 domain-containing protein Neighboring gene DUF38 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FOXO transcription factor DAF-16 bypasses ire-1 requirement to promote endoplasmic reticulum homeostasis. Safra M, et al. Cell Metab, 2014 Nov 4. PMID 25448701
  2. Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes. Eckl J, et al. PLoS One, 2017. PMID 29078207, Free PMC Article
  3. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. Liu G, et al. EMBO J, 2011 Jun 14. PMID 21673654, Free PMC Article
  4. A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans. Panek J, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32193347, Free PMC Article
  5. Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues. Androwski RJ, et al. PLoS Genet, 2020 Sep. PMID 32997655, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Skp1-related protein
NP_507393.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    17347902..17348723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074992.8 → NP_507393.1  Skp1-related protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507393.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WSZ8, Q9XU27
    Conserved Domains (2) summary
    smart00512
    Location:5 → 109
    Skp1; Found in Skp1 protein family
    pfam01466
    Location:84 → 141
    Skp1; Skp1 family, dimerization domain
Nucleotide Protein
Heading Accession and Version

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