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Y43F8B.2 GSKIP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180278, updated on 2-Nov-2024

Summary

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Official Symbol
Y43F8B.2
Official Full Name
GSKIP domain-containing protein
Primary source
WormBase:WBGene00012813
Locus tag
CELE_Y43F8B.2
See related
AllianceGenome:WB:WBGene00012813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kinase regulator activity and protein kinase A binding activity. Involved in innate immune response. Located in striated muscle dense body. Is expressed in several structures, including nerve ring; tail hypodermis; and ventral nerve cord. Orthologous to human GSKIP (GSK3B interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y43F8B.2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (19519938..19533110, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene ncRNA Neighboring gene MIF4G domain-containing protein;Prion-like-(Q/N-rich)-domain-bearing protein;Titin;ZM domain-containing protein Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
involved_in regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
GSKIP domain-containing protein
NP_001123045.1
  • Confirmed by transcript evidence
NP_001256875.1
  • Confirmed by transcript evidence
NP_001256876.1
  • Confirmed by transcript evidence
NP_001256877.1
  • Confirmed by transcript evidence
NP_001379035.1
  • Confirmed by transcript evidence
NP_507796.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    19519938..19533110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392701.1 → NP_001379035.1  GSKIP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWX6
    Conserved Domains (1) summary
    pfam05303
    Location:83 → 186
    DUF727; Protein of unknown function (DUF727)

  2. NM_075395.5 → NP_507796.1  GSKIP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507796.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWX7
    Conserved Domains (1) summary
    pfam05303
    Location:156 → 259
    DUF727; Protein of unknown function (DUF727)

  3. NM_001269946.4 → NP_001256875.1  GSKIP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D9PTN9
    Conserved Domains (1) summary
    pfam05303
    Location:135 → 238
    DUF727; Protein of unknown function (DUF727)

  4. NM_001129573.4 → NP_001123045.1  GSKIP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123045.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B1V8J2
    Conserved Domains (1) summary
    pfam05303
    Location:49 → 152
    DUF727; Protein of unknown function (DUF727)

  5. NM_001269947.3 → NP_001256876.1  GSKIP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D9PTP0
    Conserved Domains (1) summary
    pfam05303
    Location:26 → 129
    DUF727; Protein of unknown function (DUF727)

  6. NM_001269948.3 → NP_001256877.1  GSKIP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256877.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D9PTP1
    Conserved Domains (1) summary
    pfam05303
    Location:1 → 81
    DUF727; Protein of unknown function (DUF727)
Nucleotide Protein
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