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kcnl-1 Calmodulin-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180280, updated on 2-Nov-2024

Summary

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Official Symbol
kcnl-1
Official Full Name
Calmodulin-binding domain-containing protein
Primary source
WormBase:WBGene00007176
Locus tag
CELE_B0399.1
See related
AllianceGenome:WB:WBGene00007176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in body wall musculature; neurons; and non-striated muscle. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kcnl-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
18
Sequence:
Chromosome: V; NC_003283.11 (19565382..19606124)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene Glycine Rich Secreted Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A single-nucleotide change underlies the genetic assimilation of a plastic trait. Vigne P, et al. Sci Adv, 2021 Feb. PMID 33536214, Free PMC Article
  2. Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off. Mignerot L, et al. Elife, 2024 Apr 2. PMID 38564369, Free PMC Article
  3. Determining genetic expression profiles in C. elegans using microarray and real-time PCR. Guthmueller KL, et al. J Vis Exp, 2011 Jul 30. PMID 21841763, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small conductance calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Calmodulin-binding domain-containing protein
NP_001041074.1
  • Confirmed by transcript evidence
NP_001041075.1
  • Confirmed by transcript evidence
NP_001122838.1
  • Confirmed by transcript evidence
NP_001379314.1
  • Confirmed by transcript evidence
NP_507800.2
  • Partially confirmed by transcript evidence
NP_872183.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    19565382..19606124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392703.1 → NP_001379314.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDG3
    Conserved Domains (3) summary
    smart01053
    Location:514 → 589
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:219 → 330
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:447 → 500
    Ion_trans_2; Ion channel

  2. NM_075399.5 → NP_507800.2  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507800.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFI1
    Conserved Domains (4) summary
    smart01053
    Location:561 → 636
    CaMBD; Calmodulin binding domain
    PHA03253
    Location:29 → 163
    PHA03253; UL35; Provisional
    pfam03530
    Location:266 → 377
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:494 → 547
    Ion_trans_2; Ion channel

  3. NM_001129366.4 → NP_001122838.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED53
    Conserved Domains (3) summary
    smart01053
    Location:464 → 539
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:169 → 280
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:397 → 450
    Ion_trans_2; Ion channel

  4. NM_001047609.4 → NP_001041074.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041074.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EER9
    Conserved Domains (3) summary
    smart01053
    Location:449 → 524
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:154 → 265
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:382 → 435
    Ion_trans_2; Ion channel

  5. NM_001047610.5 → NP_001041075.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEZ9
    Conserved Domains (3) summary
    smart01053
    Location:380 → 455
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:85 → 196
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:313 → 366
    Ion_trans_2; Ion channel

  6. NM_182383.5 → NP_872183.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872183.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4D2
    Conserved Domains (3) summary
    smart01053
    Location:324 → 399
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:29 → 140
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:257 → 310
    Ion_trans_2; Ion channel
Nucleotide Protein
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