unc-51 Serine/threonine-protein kinase unc-51 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-51
Official Full Name: Serine/threonine-protein kinase unc-51
Primary source: WormBase:WBGene00006786
Locus tag: CELE_Y60A3A.1
See related: AllianceGenome:WB:WBGene00006786
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of axon extension. Located in axon and neuronal cell body. Is expressed in body wall musculature; neurons; and pharyngeal muscle cell. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1) and ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-51 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (19995986..20004485, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using pharmacological and genetic approaches, we found that worms deficient for autophagy were short-lived during starvation and recovered poorly from extended starvation, indicating sensitivity to nutrient stress. Autophagy mutants unc-51/Atg1 and atg-18/Atg18 maintained greater mtDNA content than wild-type worms during starvation, suggesting that autophagy promotes mitochondrial degradation during starvation
Title: Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.
PP2A cooperates with UNC-51 to regulate axon guidance by regulating phosphorylation.
Title: Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.
Inactivation of unc-51, bec-1 and lgg-1, the worm counterparts of the yeast autophagy genes Atg1, Atg6 and Atg8 respectively, partially suppresses degeneration of neurons with toxic ion channel variants.
Title: Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
Mutants with impaired growth cone functions, such as unc-51, often exhibit abnormal terminations and inappropriate trajectories at the distal ends of the M2 axons.
Title: A genetic analysis of axon guidance in the C elegans pharynx.
The autophagy-related kinase UNC-51 regulates the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans
Title: The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.
VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth
Title: The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein kinase unc-51

NP_507869.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

19995986..20004485 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075468.7 → NP_507869.1 Serine/threonine-protein kinase unc-51 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507869.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23023

Conserved Domains (3) summary

smart00220
Location:9 → 275

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14120
Location:15 → 274

STKc_ULK1_2-like; Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins

pfam12063
Location:647 → 848

DUF3543; Domain of unknown function (DUF3543)