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ttx-1 Homeobox protein ttx-1 [ Caenorhabditis elegans ]

Gene ID: 180313, updated on 9-Dec-2024

Summary

Official Symbol
ttx-1
Official Full Name
Homeobox protein ttx-1
Primary source
WormBase:WBGene00006652
Locus tag
CELE_Y113G7A.6
See related
AllianceGenome:WB:WBGene00006652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Is expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to several human genes including OTX1 (orthodenticle homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See ttx-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (20053719..20064176, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene CX domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene NADPH-dependent diflavin oxidoreductase 1 Neighboring gene ncRNA Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Homeobox protein ttx-1
NP_001024212.1
  • Confirmed by transcript evidence
NP_001024213.1
  • Partially confirmed by transcript evidence
NP_001129914.1
  • Confirmed by transcript evidence
NP_001317838.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20053719..20064176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029042.5NP_001024213.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024213.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2Y9
    Conserved Domains (1) summary
    pfam00046
    Location:150203
    Homeobox; Homeobox domain
  2. NM_001330887.2NP_001317838.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168HA93
    Conserved Domains (1) summary
    pfam00046
    Location:191244
    Homeobox; Homeobox domain
  3. NM_001029041.3NP_001024212.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024212.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A168HA93, B5QSI6, Q95W16, Q95W17, Q95W18, Q9U2Y9, Q9U2Z0
    Conserved Domains (1) summary
    pfam00046
    Location:203256
    Homeobox; Homeobox domain
  4. NM_001136442.4NP_001129914.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5QSI6
    Conserved Domains (1) summary
    pfam00046
    Location:166219
    Homeobox; Homeobox domain