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egl-17 Uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 180402, updated on 2-Nov-2024

Summary

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Official Symbol
egl-17
Official Full Name
Uncharacterized protein
Primary source
WormBase:WBGene00001185
Locus tag
CELE_F38G1.2
See related
AllianceGenome:WB:WBGene00001185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in regulation of cell migration and regulation of egg-laying behavior. Located in extracellular space. Is expressed in several structures, including M4 neuron; P5.p; P7.p; epithelial cell; and proctodeal cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia; hypogonadotropic hypogonadism 6 with or without anosmia; and prostate carcinoma in situ. Orthologous to several human genes including FGF18 (fibroblast growth factor 18) and FGF8 (fibroblast growth factor 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egl-17 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (489685..492318)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asp Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans larvae undergo early developmental arrest on a diet of Gram-positive bacterium Enterococcus faecalis. Dasgupta M, et al. MicroPubl Biol, 2020 Oct 27. PMID 33274333, Free PMC Article
  2. FGF signaling in flies and worms: more and more relevant to vertebrate biology. Huang P, et al. Cytokine Growth Factor Rev, 2005 Apr. PMID 15863031
  3. sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans. Photos A, et al. Dev Biol, 2006 May 1. PMID 16515780
  4. A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Stern MJ, et al. Development, 1991 Nov. PMID 1821851
  5. Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity. Goodman SJ, et al. Development, 2003 Aug. PMID 12835392

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
    Title: Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans.
  2. LET-756, like vertebrate FGF9, -16, and -20, belongs to the FGF9 family, whereas EGL-17, like vertebrate FGF8, -17, and -18, could be included in the FGF8 family [review]
    Title: A pair as a minimum: the two fibroblast growth factors of the nematode Caenorhabditis elegans.
  3. Experimental studies in the egl-17 mutant background indicate a complex set of gonad-dependent and gonad-independent mechanisms required for sex myoblast migration.
    Title: sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans.
  4. EGL-17/FGF signaling through an EGL-15/FGFR isoform and possibly SEM-5/GRB2 mediates both attraction of the migrating sex myoblasts and repulsion of the migrating CAN neurons.
    Title: Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables type 1 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Uncharacterized protein
NP_508107.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    489685..492318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075706.6 → NP_508107.1  Uncharacterized protein CELE_F38G1.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEF1
    Conserved Domains (1) summary
    cl00060
    Location:31 → 159
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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