pifk-1 Phosphatidylinositol 4-kinase beta [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pifk-1
Official Full Name: Phosphatidylinositol 4-kinase beta
Primary source: WormBase:WBGene00018076
Locus tag: CELE_F35H12.4
See related: AllianceGenome:WB:WBGene00018076
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 1-phosphatidylinositol 4-kinase activity. Involved in regulation of basement membrane organization. Predicted to be located in mitochondrial outer membrane and rough endoplasmic reticulum membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including head; intestine; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 87. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

NP_508177.2

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